RNF5 — 8 ClinVar variants
All ClinVar germline RNF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
1 Likely benign · 7 Uncertain significance
Full RNF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 3
The independent predictors disagree with each other — read with care.
All RNF5 variants
Likely benign 1
- p.Arg16Cys Single submitter
Uncertain significance 7
- p.Arg58Gln Single submitter ⚠
- p.Glu26Gly Single submitter ⚠
- p.Ile180Thr Single submitter ⚠
- p.Pro78Gln Single submitter ⚠
- p.Ser123Leu Single submitter ⚠
- p.Ser179Cys Single submitter ⚠
- p.Tyr46His Single submitter ⚠