RNGTT — 47 ClinVar variants
All ClinVar germline RNGTT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 45 Uncertain significance
Full RNGTT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RNGTT p.Ala567Pro Uncertain significance Single submitter
- RNGTT p.Arg108His Uncertain significance Single submitter
- RNGTT p.Arg112Gln Uncertain significance Single submitter
- RNGTT p.Arg112Trp Uncertain significance Single submitter
- RNGTT p.Arg594His Uncertain significance Single submitter
- RNGTT p.Asn368Ser Uncertain significance Single submitter
- RNGTT p.Asn521Lys Uncertain significance Single submitter
- RNGTT p.Asp277Glu Uncertain significance Single submitter
- RNGTT p.Asp511Gly Uncertain significance Single submitter
- RNGTT p.Asp563Asn Uncertain significance Single submitter
- RNGTT p.Gln254Glu Uncertain significance Single submitter
- RNGTT p.Gln255Arg Uncertain significance Single submitter
- RNGTT p.Gln405Arg Uncertain significance Single submitter
- RNGTT p.Gln570Glu Uncertain significance Single submitter
- RNGTT p.Glu115Asp Uncertain significance Single submitter
- RNGTT p.Glu432Gln Uncertain significance Single submitter
- RNGTT p.Glu583Gly Uncertain significance Single submitter
- RNGTT p.Gly206Arg Uncertain significance Single submitter
- RNGTT p.Gly206Glu Uncertain significance Single submitter
- RNGTT p.His393Tyr Uncertain significance Single submitter
- RNGTT p.His576Gln Uncertain significance Single submitter
- RNGTT p.His576Tyr Uncertain significance Single submitter
- RNGTT p.Ile107Val Uncertain significance Single submitter
- RNGTT p.Leu578Pro Uncertain significance Single submitter
- RNGTT p.Leu57Ile Uncertain significance Single submitter
- RNGTT p.Lys171Arg Uncertain significance Single submitter
- RNGTT p.Lys403Arg Uncertain significance Single submitter
- RNGTT p.Lys575Asn Uncertain significance Single submitter
- RNGTT p.Phe174Leu Uncertain significance Single submitter
- RNGTT p.Pro187Leu Uncertain significance Single submitter
- RNGTT p.Pro212Arg Uncertain significance Single submitter
- RNGTT p.Ser214Pro Uncertain significance Single submitter
- RNGTT p.Thr155Ala Uncertain significance Single submitter
- RNGTT p.Thr445Ala Uncertain significance Single submitter
- RNGTT p.Val253Ala Uncertain significance Single submitter
- RNGTT p.Val410Ile Uncertain significance Single submitter
- RNGTT p.Val525Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- RNGTT p.Arg175Cys Uncertain significance Single submitter
- RNGTT p.Arg225Trp Uncertain significance Single submitter
- RNGTT p.Arg470Cys Uncertain significance Single submitter
- RNGTT p.Asp36Asn Uncertain significance Single submitter
- RNGTT p.Gly240Ser Uncertain significance Single submitter
- RNGTT p.Ile389Met Uncertain significance Single submitter
- RNGTT p.Ile389Thr Uncertain significance Single submitter
- RNGTT p.Ser56Ile Uncertain significance Single submitter
All RNGTT variants
Likely benign 2
- p.Gly265= Single submitter
- p.Thr445Ile Single submitter
Uncertain significance 45
- p.Ala567Pro Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg112Gln Single submitter ⚠
- p.Arg112Trp Single submitter ⚠
- p.Arg175Cys Single submitter ⚠
- p.Arg225Trp Single submitter ⚠
- p.Arg470Cys Single submitter ⚠
- p.Arg594His Single submitter ⚠
- p.Asn368Ser Single submitter ⚠
- p.Asn521Lys Single submitter ⚠
- p.Asp277Glu Single submitter ⚠
- p.Asp36Asn Single submitter ⚠
- p.Asp511Gly Single submitter ⚠
- p.Asp563Asn Single submitter ⚠
- p.Gln254Glu Single submitter ⚠
- p.Gln255Arg Single submitter ⚠
- p.Gln405Arg Single submitter ⚠
- p.Gln570Glu Single submitter ⚠
- p.Glu115Asp Single submitter ⚠
- p.Glu432Gln Single submitter ⚠
- p.Glu583Gly Single submitter ⚠
- p.Gly206Arg Single submitter ⚠
- p.Gly206Glu Single submitter ⚠
- p.Gly240Ser Single submitter ⚠
- p.His393Tyr Single submitter ⚠
- p.His576Gln Single submitter ⚠
- p.His576Tyr Single submitter ⚠
- p.Ile107Val Single submitter ⚠
- p.Ile389Met Single submitter ⚠
- p.Ile389Thr Single submitter ⚠
- p.Leu578Pro Single submitter ⚠
- p.Leu57Ile Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Lys403Arg Single submitter ⚠
- p.Lys575Asn Single submitter ⚠
- p.Phe174Leu Single submitter ⚠
- p.Pro187Leu Single submitter ⚠
- p.Pro212Arg Single submitter ⚠
- p.Ser214Pro Single submitter ⚠
- p.Ser56Ile Single submitter ⚠
- p.Thr155Ala Single submitter ⚠
- p.Thr445Ala Single submitter ⚠
- p.Val253Ala Single submitter ⚠
- p.Val410Ile Single submitter ⚠
- p.Val525Ile Single submitter ⚠