RNLS — 98 ClinVar variants
All ClinVar germline RNLS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
3 Conflicting · 27 Benign · 1 Benign/Likely benign · 14 Likely benign · 53 Uncertain significance
Full RNLS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 3
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RNLS p.Asp102Glu Uncertain significance Multiple submitters
- RNLS p.His307Leu Uncertain significance Multiple submitters
- RNLS p.Ser217Gly Uncertain significance Multiple submitters
- RNLS p.Thr160Pro Uncertain significance Multiple submitters
- RNLS p.Ala70Ser Uncertain significance Single submitter
- RNLS p.Ala70Val Uncertain significance Single submitter
- RNLS p.Arg193Gln Uncertain significance Single submitter
- RNLS p.Arg231Cys Uncertain significance Single submitter
- RNLS p.Arg75Cys Uncertain significance Single submitter
- RNLS p.Cys220Arg Uncertain significance Single submitter
- RNLS p.Gln134His Uncertain significance Single submitter
- RNLS p.Gln147Lys Uncertain significance Single submitter
- RNLS p.Gln268Glu Uncertain significance Single submitter
- RNLS p.Glu256Asp Uncertain significance Single submitter
- RNLS p.Gly95Val Uncertain significance Single submitter
- RNLS p.His245Tyr Uncertain significance Single submitter
- RNLS p.Ile135Asn Uncertain significance Single submitter
- RNLS p.Ile226Val Uncertain significance Single submitter
- RNLS p.Ile233Val Uncertain significance Single submitter
- RNLS p.Leu270Arg Uncertain significance Single submitter
- RNLS p.Leu80Pro Uncertain significance Single submitter
- RNLS p.Lys230Asn Uncertain significance Single submitter
- RNLS p.Lys72Ile Uncertain significance Single submitter
- RNLS p.Met11Arg Uncertain significance Single submitter
- RNLS p.Pro240Ser Uncertain significance Single submitter
- RNLS p.Ser291Thr Uncertain significance Single submitter
- RNLS p.Thr175Ile Uncertain significance Single submitter
- RNLS p.Thr45Ile Uncertain significance Single submitter
- RNLS p.Trp142Gly Uncertain significance Single submitter
- RNLS p.Val266Asp Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- RNLS p.Ile226Thr Uncertain significance Multiple submitters
- RNLS p.Leu335Pro Uncertain significance Multiple submitters
- RNLS p.Pro249Leu Uncertain significance Multiple submitters
- RNLS p.Arg222Cys Uncertain significance Single submitter
- RNLS p.Arg222His Uncertain significance Single submitter
- RNLS p.Asp155Asn Uncertain significance Single submitter
- RNLS p.Asp155Glu Uncertain significance Single submitter
- RNLS p.Cys54Gly Uncertain significance Single submitter
- RNLS p.Leu198Val Uncertain significance Single submitter
- RNLS p.Leu19Val Uncertain significance Single submitter
- RNLS p.Leu28Phe Uncertain significance Single submitter
- RNLS p.Leu58Phe Uncertain significance Single submitter
- RNLS p.Met43Thr Uncertain significance Single submitter
- RNLS p.Pro280Ala Uncertain significance Single submitter
- RNLS p.Pro49Arg Uncertain significance Single submitter
- RNLS p.Ser235Leu Uncertain significance Single submitter
- RNLS p.Thr204Met Uncertain significance Single submitter
- RNLS p.Thr66Pro Uncertain significance Single submitter
- RNLS p.Tyr254Cys Uncertain significance Single submitter
- RNLS p.Val188Ala Uncertain significance Single submitter
- RNLS p.Val248Ile Uncertain significance Single submitter
All RNLS variants
Conflicting classifications of pathogenicity 3
- p.Ile93Val Single submitter ⚠
- p.Val224Ile Single submitter ⚠
- p.Val85Ile Single submitter ⚠
Benign 27
- c.224+115A>G Multiple submitters
- c.526+49T>C Multiple submitters
- c.527-30G>A Multiple submitters
- c.701-3C>T Multiple submitters
- c.876+78T>C Multiple submitters
- c.876+83C>T Multiple submitters
- c.877-110G>A Multiple submitters
- c.877-94G>A Multiple submitters
- c.*173T>A Multiple submitters
- c.*230T>C Multiple submitters
- c.*270G>A Multiple submitters
- p.Asp207Glu Multiple submitters
- p.Gln181Lys Multiple submitters
- p.Glu37Asp Multiple submitters end stage renal failure
- c.367+251TA[12] Single submitter
- c.367+271_367+276del Single submitter
- c.367+273C>T Single submitter
- c.367+275C>T Single submitter
- c.368-227A>T Single submitter
- c.527-194A>G Single submitter
- c.701-9A>G Single submitter
- c.876+218T>C Single submitter
- c.876+237C>T Single submitter
- c.877-194del Single submitter
- c.877-220T>A Single submitter
- c.877-249C>T Single submitter
- p.Gln53= Single submitter
Benign/Likely benign 1
- p.Ile111Thr Multiple submitters
Likely benign 14
- c.368-110A>C Multiple submitters
- c.*231G>A Multiple submitters
- p.Gln269Ter Multiple submitters
- c.118+222_118+233del Single submitter
- c.119-176T>C Single submitter
- c.119-222A>T Single submitter
- c.526+11T>C Single submitter
- c.876+20G>A Single submitter
- p.Ala313= Single submitter
- p.Asn232Ser Single submitter
- p.Gln134= Single submitter
- p.Leu242= Single submitter
- p.Lys146Arg Single submitter
- p.Phe223= Single submitter
Uncertain significance 53
- p.Asp102Glu Multiple submitters ⚠
- p.His307Leu Multiple submitters ⚠
- p.Ile226Thr Multiple submitters ⚠
- p.Leu335Pro Multiple submitters ⚠
- p.Pro249Leu Multiple submitters ⚠
- p.Ser217Gly Multiple submitters ⚠
- p.Thr160Pro Multiple submitters ⚠
- p.Ala70Ser Single submitter ⚠
- p.Ala70Val Single submitter ⚠
- p.Arg193Gln Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg222His Single submitter ⚠
- p.Arg231Cys Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Asp155Asn Single submitter ⚠
- p.Asp155Glu Single submitter ⚠
- p.Cys220Arg Single submitter ⚠
- p.Cys54Gly Single submitter ⚠
- p.Gln134His Single submitter ⚠
- p.Gln147Lys Single submitter ⚠
- p.Gln268Glu Single submitter ⚠
- p.Glu256Asp Single submitter ⚠
- p.Gly95Val Single submitter ⚠
- p.His245Tyr Single submitter ⚠
- p.Ile135Asn Single submitter ⚠
- p.Ile226Val Single submitter ⚠
- p.Ile233Val Single submitter ⚠
- p.Leu198Val Single submitter ⚠
- p.Leu19Val Single submitter ⚠
- p.Leu270Arg Single submitter ⚠
- p.Leu28Phe Single submitter ⚠
- p.Leu338Ser Single submitter
- p.Leu58Phe Single submitter ⚠
- p.Leu80Pro Single submitter ⚠
- p.Lys230Asn Single submitter ⚠
- p.Lys72Ile Single submitter ⚠
- p.Met11Arg Single submitter ⚠
- p.Met43Thr Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Pro280Ala Single submitter ⚠
- p.Pro49Arg Single submitter ⚠
- p.Ser235Leu Single submitter ⚠
- p.Ser291Thr Single submitter ⚠
- p.Thr175Ile Single submitter ⚠
- p.Thr204Met Single submitter ⚠
- p.Thr45Ile Single submitter ⚠
- p.Thr66Pro Single submitter ⚠
- p.Trp142Gly Single submitter ⚠
- p.Tyr254Cys Single submitter ⚠
- p.Val188Ala Single submitter ⚠
- p.Val243Met Single submitter
- p.Val248Ile Single submitter ⚠
- p.Val266Asp Single submitter ⚠