RNMT — 59 ClinVar variants
All ClinVar germline RNMT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
2 Benign · 2 Likely benign · 55 Uncertain significance
Full RNMT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RNMT p.Ala2Thr Uncertain significance Single submitter
- RNMT p.Ala56Thr Uncertain significance Single submitter
- RNMT p.Arg239Trp Uncertain significance Single submitter
- RNMT p.Asn31Thr Uncertain significance Single submitter
- RNMT p.Asp133Asn Uncertain significance Single submitter
- RNMT p.Asp359His Uncertain significance Single submitter
- RNMT p.Asp64Asn Uncertain significance Single submitter
- RNMT p.Cys225Ser Uncertain significance Single submitter
- RNMT p.Cys287Tyr Uncertain significance Single submitter
- RNMT p.Cys73Tyr Uncertain significance Single submitter
- RNMT p.Gln193Glu Uncertain significance Single submitter
- RNMT p.Glu397Asp Uncertain significance Single submitter
- RNMT p.Glu460Asp Uncertain significance Single submitter
- RNMT p.Glu61Val Uncertain significance Single submitter
- RNMT p.Gly122Ser Uncertain significance Single submitter
- RNMT p.Ile129Val Uncertain significance Single submitter
- RNMT p.Ile184Phe Uncertain significance Single submitter
- RNMT p.Ile228Thr Uncertain significance Single submitter
- RNMT p.Ile466Ser Uncertain significance Single submitter
- RNMT p.Leu156Ile Uncertain significance Single submitter
- RNMT p.Leu156Pro Uncertain significance Single submitter
- RNMT p.Lys196Thr Uncertain significance Single submitter
- RNMT p.Lys6Gln Uncertain significance Single submitter
- RNMT p.Met276Ile Uncertain significance Single submitter
- RNMT p.Phe314Val Uncertain significance Single submitter
- RNMT p.Phe395Leu Uncertain significance Single submitter
- RNMT p.Phe62Cys Uncertain significance Single submitter
- RNMT p.Pro420Ser Uncertain significance Single submitter
- RNMT p.Ser21Leu Uncertain significance Single submitter
- RNMT p.Trp461Cys Uncertain significance Single submitter
- RNMT p.Val149Ala Uncertain significance Single submitter
- RNMT p.Val365Gly Uncertain significance Single submitter
- RNMT p.Val49Ile Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- RNMT p.Ala151Val Uncertain significance Single submitter
- RNMT p.Arg107Gly Uncertain significance Single submitter
- RNMT p.Arg247Cys Uncertain significance Single submitter
- RNMT p.Asn320Ser Uncertain significance Single submitter
- RNMT p.Asn361Ser Uncertain significance Single submitter
- RNMT p.Asp198Tyr Uncertain significance Single submitter
- RNMT p.Gln238Pro Uncertain significance Single submitter
- RNMT p.Gln346Arg Uncertain significance Single submitter
- RNMT p.Glu400Lys Uncertain significance Single submitter
- RNMT p.Gly349Arg Uncertain significance Single submitter
- RNMT p.Ile403Met Uncertain significance Single submitter
- RNMT p.Lys12Arg Uncertain significance Single submitter
- RNMT p.Lys216Thr Uncertain significance Single submitter
- RNMT p.Lys428Glu Uncertain significance Single submitter
- RNMT p.Lys445Arg Uncertain significance Single submitter
- RNMT p.Met243Val Uncertain significance Single submitter
- RNMT p.Met300Val Uncertain significance Single submitter
- RNMT p.Phe322Leu Uncertain significance Single submitter
- RNMT p.Ser14Phe Uncertain significance Single submitter
- RNMT p.Ser254Asn Likely benign Single submitter
- RNMT p.Tyr240Phe Uncertain significance Single submitter
- RNMT p.Tyr391Cys Uncertain significance Single submitter
- RNMT p.Val469Met Uncertain significance Single submitter
All RNMT variants
Likely benign 2
- p.Glu460= Single submitter
- p.Ser254Asn Single submitter ⚠
Uncertain significance 55
- p.Ala151Val Single submitter ⚠
- p.Ala2Thr Single submitter ⚠
- p.Ala56Thr Single submitter ⚠
- p.Arg107Gly Single submitter ⚠
- p.Arg239Trp Single submitter ⚠
- p.Arg247Cys Single submitter ⚠
- p.Asn31Thr Single submitter ⚠
- p.Asn320Ser Single submitter ⚠
- p.Asn361Ser Single submitter ⚠
- p.Asp133Asn Single submitter ⚠
- p.Asp198Tyr Single submitter ⚠
- p.Asp359His Single submitter ⚠
- p.Asp64Asn Single submitter ⚠
- p.Cys225Ser Single submitter ⚠
- p.Cys287Tyr Single submitter ⚠
- p.Cys73Tyr Single submitter ⚠
- p.Gln193Glu Single submitter ⚠
- p.Gln238Pro Single submitter ⚠
- p.Gln346Arg Single submitter ⚠
- p.Glu397Asp Single submitter ⚠
- p.Glu400Lys Single submitter ⚠
- p.Glu460Asp Single submitter ⚠
- p.Glu61Val Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly349Arg Single submitter ⚠
- p.Ile129Val Single submitter ⚠
- p.Ile184Phe Single submitter ⚠
- p.Ile228Thr Single submitter ⚠
- p.Ile403Met Single submitter ⚠
- p.Ile466Ser Single submitter ⚠
- p.Leu156Ile Single submitter ⚠
- p.Leu156Pro Single submitter ⚠
- p.Lys12Arg Single submitter ⚠
- p.Lys196Thr Single submitter ⚠
- p.Lys216Thr Single submitter ⚠
- p.Lys428Glu Single submitter ⚠
- p.Lys445Arg Single submitter ⚠
- p.Lys6Gln Single submitter ⚠
- p.Met243Val Single submitter ⚠
- p.Met276Ile Single submitter ⚠
- p.Met300Val Single submitter ⚠
- p.Phe314Val Single submitter ⚠
- p.Phe322Leu Single submitter ⚠
- p.Phe395Leu Single submitter ⚠
- p.Phe62Cys Single submitter ⚠
- p.Pro420Ser Single submitter ⚠
- p.Ser14Phe Single submitter ⚠
- p.Ser21Leu Single submitter ⚠
- p.Trp461Cys Single submitter ⚠
- p.Tyr240Phe Single submitter ⚠
- p.Tyr391Cys Single submitter ⚠
- p.Val149Ala Single submitter ⚠
- p.Val365Gly Single submitter ⚠
- p.Val469Met Single submitter ⚠
- p.Val49Ile Single submitter ⚠