ROCK2 — 119 ClinVar variants
All ClinVar germline ROCK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
1 Conflicting · 6 Benign · 9 Likely benign · 103 Uncertain significance
Full ROCK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ROCK2 p.Ala1013Thr Uncertain significance Single submitter
- ROCK2 p.Ala1018Thr Uncertain significance Single submitter
- ROCK2 p.Ala663Thr Uncertain significance Single submitter
- ROCK2 p.Arg1050His Uncertain significance Single submitter
- ROCK2 p.Arg110Cys Uncertain significance Single submitter
- ROCK2 p.Arg1294Cys Uncertain significance Single submitter
- ROCK2 p.Arg1343Gln Uncertain significance Single submitter
- ROCK2 p.Arg1377Gln Uncertain significance Single submitter
- ROCK2 p.Arg476Ser Uncertain significance Single submitter
- ROCK2 p.Arg580Trp Uncertain significance Single submitter
- ROCK2 p.Asn439Asp Uncertain significance Single submitter
- ROCK2 p.Asn568Ser Uncertain significance Single submitter
- ROCK2 p.Asn832Ser Uncertain significance Single submitter
- ROCK2 p.Asp432Glu Uncertain significance Single submitter
- ROCK2 p.Asp604Asn Uncertain significance Single submitter
- ROCK2 p.Cys1274Arg Uncertain significance Single submitter
- ROCK2 p.Cys649Arg Uncertain significance Single submitter
- ROCK2 p.Gln107Arg Uncertain significance Single submitter
- ROCK2 p.Gln350Pro Uncertain significance Single submitter
-
ROCK2 p.Gln863Pro
Uncertain significance
Single submitter
ROCK2-related disorder
- ROCK2 p.Glu440Lys Uncertain significance Single submitter
- ROCK2 p.Glu952Ala Uncertain significance Single submitter
- ROCK2 p.Glu973Asp Uncertain significance Single submitter
- ROCK2 p.His1127Arg Uncertain significance Single submitter
- ROCK2 p.His455Arg Uncertain significance Single submitter
- ROCK2 p.Ile1298Val Uncertain significance Single submitter
- ROCK2 p.Ile205Val Uncertain significance Single submitter
- ROCK2 p.Ile399Val Uncertain significance Single submitter
- ROCK2 p.Ile640Arg Uncertain significance Single submitter
- ROCK2 p.Ile697Arg Uncertain significance Single submitter
- ROCK2 p.Ile697Thr Uncertain significance Single submitter
- ROCK2 p.Leu1267Phe Uncertain significance Single submitter
- ROCK2 p.Leu540Arg Uncertain significance Single submitter
- ROCK2 p.Leu661Ser Uncertain significance Single submitter
- ROCK2 p.Leu715Arg Uncertain significance Single submitter
- ROCK2 p.Lys1307Arg Uncertain significance Single submitter
- ROCK2 p.Lys1339Gln Uncertain significance Single submitter
- ROCK2 p.Lys323Glu Uncertain significance Single submitter
- ROCK2 p.Lys391Arg Uncertain significance Single submitter
- ROCK2 p.Lys438Arg Uncertain significance Single submitter
- ROCK2 p.Lys479Arg Uncertain significance Single submitter
- ROCK2 p.Lys545Arg Uncertain significance Single submitter
- ROCK2 p.Lys556Ile Uncertain significance Single submitter
- ROCK2 p.Lys734Arg Uncertain significance Single submitter
- ROCK2 p.Lys80Glu Uncertain significance Single submitter
- ROCK2 p.Met120Val Uncertain significance Single submitter
- ROCK2 p.Met1367Val Uncertain significance Single submitter
- ROCK2 p.Met244Ile Uncertain significance Single submitter
- ROCK2 p.Met733Leu Uncertain significance Single submitter
- ROCK2 p.Met839Ile Uncertain significance Single submitter
- ROCK2 p.Phe676Tyr Uncertain significance Single submitter
- ROCK2 p.Pro1314Ser Uncertain significance Single submitter
- ROCK2 p.Pro1363Leu Uncertain significance Single submitter
- ROCK2 p.Ser1133Ala Uncertain significance Single submitter
- ROCK2 p.Ser312Thr Uncertain significance Single submitter
- ROCK2 p.Ser937Pro Uncertain significance Single submitter
- ROCK2 p.Thr1323Ala Uncertain significance Single submitter
- ROCK2 p.Thr235Lys Uncertain significance Single submitter
- ROCK2 p.Thr367Met Uncertain significance Single submitter
- ROCK2 p.Thr962Met Uncertain significance Single submitter
- ROCK2 p.Trp1282Cys Uncertain significance Single submitter
- ROCK2 p.Tyr1318Cys Uncertain significance Single submitter
- ROCK2 p.Tyr722Cys Uncertain significance Single submitter
- ROCK2 p.Tyr75Cys Uncertain significance Single submitter
- ROCK2 p.Val1048Ile Uncertain significance Single submitter
- ROCK2 p.Val1249Ala Uncertain significance Single submitter
- ROCK2 p.Val494Met Uncertain significance Single submitter
- ROCK2 p.Val750Leu Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- ROCK2 p.Ala663Val Uncertain significance Single submitter
- ROCK2 p.Arg1295His Uncertain significance Single submitter
- ROCK2 p.Arg273Gln Uncertain significance Single submitter
- ROCK2 p.Arg476Cys Uncertain significance Single submitter
- ROCK2 p.Arg881Thr Uncertain significance Single submitter
- ROCK2 p.Asn148Ser Uncertain significance Single submitter
- ROCK2 p.Asp240His Uncertain significance Single submitter
- ROCK2 p.Asp318Tyr Uncertain significance Single submitter
-
ROCK2 p.Asp601Val
Conflicting
Single submitter
volvulus of midgut
- ROCK2 p.Cys1257Gly Uncertain significance Single submitter
- ROCK2 p.Gln1122Leu Uncertain significance Single submitter
- ROCK2 p.Gln561Arg Uncertain significance Single submitter
- ROCK2 p.Gln585Arg Uncertain significance Single submitter
- ROCK2 p.Glu1188Gly Uncertain significance Single submitter
- ROCK2 p.Glu514Gly Uncertain significance Single submitter
- ROCK2 p.Glu619Lys Uncertain significance Single submitter
- ROCK2 p.Glu751Asp Uncertain significance Single submitter
- ROCK2 p.Glu842Val Uncertain significance Single submitter
- ROCK2 p.His1127Pro Uncertain significance Single submitter
- ROCK2 p.Ile129Met Uncertain significance Single submitter
- ROCK2 p.Ile917Asn Uncertain significance Single submitter
-
ROCK2 p.Ile944Phe
Uncertain significance
Single submitter
ROCK2-related disorder
- ROCK2 p.Ile968Val Uncertain significance Single submitter
- ROCK2 p.Leu616Ile Uncertain significance Single submitter
- ROCK2 p.Lys116Thr Uncertain significance Single submitter
- ROCK2 p.Lys782Glu Uncertain significance Single submitter
- ROCK2 p.Phe136Cys Likely benign Single submitter
- ROCK2 p.Ser457Gly Uncertain significance Single submitter
- ROCK2 p.Ser629Cys Uncertain significance Single submitter
- ROCK2 p.Ser700Gly Uncertain significance Single submitter
- ROCK2 p.Val168Ile Uncertain significance Single submitter
-
ROCK2 p.Thr793Ile
Uncertain significance
No assertion criteria
ROCK2-related disorder
All ROCK2 variants
Conflicting classifications of pathogenicity 1
- p.Asp601Val Single submitter volvulus of midgut ⚠
Benign 6
- c.3609-11A>C Multiple submitters
- p.Thr431Asn Multiple submitters
- c.2620-6A>G No assertion criteria ROCK2-related disorder
- p.Ala145= No assertion criteria ROCK2-related disorder
- p.Ile1202= No assertion criteria ROCK2-related disorder
- p.Leu820= No assertion criteria ROCK2-related disorder
Likely benign 9
- p.Met690Lys Single submitter
- p.Phe136Cys Single submitter ⚠
- c.1332+8G>T No assertion criteria ROCK2-related disorder
- c.1689+9A>C No assertion criteria ROCK2-related disorder
- c.2550-8C>G No assertion criteria ROCK2-related disorder
- c.3688-5C>T No assertion criteria ROCK2-related disorder
- p.Glu861= No assertion criteria ROCK2-related disorder
- p.Leu623= No assertion criteria ROCK2-related disorder
- p.Ser724= No assertion criteria ROCK2-related disorder
Uncertain significance 103
- p.Ala1013Thr Single submitter ⚠
- p.Ala1018Thr Single submitter ⚠
- p.Ala663Thr Single submitter ⚠
- p.Ala663Val Single submitter ⚠
- p.Arg1044Ter Single submitter non-immune hydrops fetalis
- p.Arg1050His Single submitter ⚠
- p.Arg110Cys Single submitter ⚠
- p.Arg1294Cys Single submitter ⚠
- p.Arg1295His Single submitter ⚠
- p.Arg1343Gln Single submitter ⚠
- p.Arg1377Gln Single submitter ⚠
- p.Arg273Gln Single submitter ⚠
- p.Arg476Cys Single submitter ⚠
- p.Arg476Ser Single submitter ⚠
- p.Arg527Ter Single submitter non-immune hydrops fetalis
- p.Arg580Trp Single submitter ⚠
- p.Arg714Ter Single submitter
- p.Arg881Thr Single submitter ⚠
- p.Asn148Ser Single submitter ⚠
- p.Asn439Asp Single submitter ⚠
- p.Asn568Ser Single submitter ⚠
- p.Asn832Ser Single submitter ⚠
- p.Asn975Ter Single submitter
- p.Asp240His Single submitter ⚠
- p.Asp318Tyr Single submitter ⚠
- p.Asp432Glu Single submitter ⚠
- p.Asp604Asn Single submitter ⚠
- p.Cys1257Gly Single submitter ⚠
- p.Cys1274Arg Single submitter ⚠
- p.Cys649Arg Single submitter ⚠
- p.Gln107Arg Single submitter ⚠
- p.Gln1122Leu Single submitter ⚠
- p.Gln350Pro Single submitter ⚠
- p.Gln561Arg Single submitter ⚠
- p.Gln585Arg Single submitter ⚠
- p.Gln863Pro Single submitter ROCK2-related disorder ⚠
- p.Glu1188Gly Single submitter ⚠
- p.Glu440Lys Single submitter ⚠
- p.Glu514Gly Single submitter ⚠
- p.Glu619Lys Single submitter ⚠
- p.Glu751Asp Single submitter ⚠
- p.Glu842Val Single submitter ⚠
- p.Glu952Ala Single submitter ⚠
- p.Glu973Asp Single submitter ⚠
- p.His1127Arg Single submitter ⚠
- p.His1127Pro Single submitter ⚠
- p.His455Arg Single submitter ⚠
- p.Ile1298Val Single submitter ⚠
- p.Ile129Met Single submitter ⚠
- p.Ile205Val Single submitter ⚠
- p.Ile399Val Single submitter ⚠
- p.Ile640Arg Single submitter ⚠
- p.Ile697Arg Single submitter ⚠
- p.Ile697Thr Single submitter ⚠
- p.Ile917Asn Single submitter ⚠
- p.Ile944Phe Single submitter ROCK2-related disorder ⚠
- p.Ile968Val Single submitter ⚠
- p.Leu1267Phe Single submitter ⚠
- p.Leu540Arg Single submitter ⚠
- p.Leu616Ile Single submitter ⚠
- p.Leu661Ser Single submitter ⚠
- p.Leu715Arg Single submitter ⚠
- p.Lys116Thr Single submitter ⚠
- p.Lys1307Arg Single submitter ⚠
- p.Lys1339Gln Single submitter ⚠
- p.Lys323Glu Single submitter ⚠
- p.Lys391Arg Single submitter ⚠
- p.Lys438Arg Single submitter ⚠
- p.Lys479Arg Single submitter ⚠
- p.Lys545Arg Single submitter ⚠
- p.Lys556Ile Single submitter ⚠
- p.Lys734Arg Single submitter ⚠
- p.Lys782Glu Single submitter ⚠
- p.Lys80Glu Single submitter ⚠
- p.Met120Val Single submitter ⚠
- p.Met1367Val Single submitter ⚠
- p.Met244Ile Single submitter ⚠
- p.Met733Leu Single submitter ⚠
- p.Met839Ile Single submitter ⚠
- p.Phe676Tyr Single submitter ⚠
- p.Pro1314Ser Single submitter ⚠
- p.Pro1363Leu Single submitter ⚠
- p.Ser1133Ala Single submitter ⚠
- p.Ser312Thr Single submitter ⚠
- p.Ser457Gly Single submitter ⚠
- p.Ser629Cys Single submitter ⚠
- p.Ser700Gly Single submitter ⚠
- p.Ser937Pro Single submitter ⚠
- p.Thr1323Ala Single submitter ⚠
- p.Thr235Lys Single submitter ⚠
- p.Thr367Met Single submitter ⚠
- p.Thr962Met Single submitter ⚠
- p.Trp1282Cys Single submitter ⚠
- p.Tyr1318Cys Single submitter ⚠
- p.Tyr722Cys Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Val1048Ile Single submitter ⚠
- p.Val1249Ala Single submitter ⚠
- p.Val168Ile Single submitter ⚠
- p.Val494Met Single submitter ⚠
- p.Val750Leu Single submitter ⚠
- p.Gln1242Ter No assertion criteria dextrocardia
- p.Thr793Ile No assertion criteria ROCK2-related disorder ⚠