RPA3 — 14 ClinVar variants
All ClinVar germline RPA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
1 Likely benign · 13 Uncertain significance
Full RPA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPA3 p.Gln119Arg Uncertain significance Single submitter
- RPA3 p.Glu101Lys Uncertain significance Single submitter
- RPA3 p.Glu57Gly Uncertain significance Single submitter
- RPA3 p.Gly116Arg Uncertain significance Single submitter
- RPA3 p.Ile105Met Uncertain significance Single submitter
- RPA3 p.Met5Thr Uncertain significance Single submitter
- RPA3 p.Pro110Ala Uncertain significance Single submitter
- RPA3 p.Pro36Ala Uncertain significance Single submitter
- RPA3 p.Thr74Ile Uncertain significance Single submitter
- RPA3 p.Tyr113Ser Uncertain significance Single submitter
- RPA3 p.Val2Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RPA3 variants
Likely benign 1
- p.Ser91Asn Single submitter
Uncertain significance 13
- p.Gln119Arg Single submitter ⚠
- p.Glu101Lys Single submitter ⚠
- p.Glu57Gly Single submitter ⚠
- p.Gly116Arg Single submitter ⚠
- p.Gly46Val Single submitter ⚠
- p.Ile105Met Single submitter ⚠
- p.Met5Thr Single submitter ⚠
- p.Pro110Ala Single submitter ⚠
- p.Pro36Ala Single submitter ⚠
- p.Pro58Ser Single submitter ⚠
- p.Thr74Ile Single submitter ⚠
- p.Tyr113Ser Single submitter ⚠
- p.Val2Met Single submitter ⚠