Sugi Variant

Sugi Variant/RPL10

RPL10 — 84 ClinVar variants

All ClinVar germline RPL10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →

5 Pathogenic · 4 Likely pathogenic · 1 Conflicting · 5 Benign · 2 Benign/Likely benign · 20 Likely benign · 47 Uncertain significance

Full RPL10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 32

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors lean, ClinVar uncertain 21

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All RPL10 variants

Pathogenic 5

  • p.His95Tyr Single submitter autism, susceptibility to, X-linked 5
  • p.Lys78Glu Single submitter intellectual disability, X-linked, syndromic, 35
  • p.Ala151Val No assertion criteria intellectual disability, X-linked, syndromic, 35
  • p.Ala64Val No assertion criteria intellectual disability, X-linked, syndromic, 35
  • p.Gly161Ser No assertion criteria intellectual disability, X-linked, syndromic, 35

Likely pathogenic 4

Conflicting classifications of pathogenicity 1

  • p.Ile97= Single submitter Inborn genetic diseases

Benign 5

Benign/Likely benign 2

Likely benign 20

Uncertain significance 47