RPL10A — 9 ClinVar variants
All ClinVar germline RPL10A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
9 Uncertain significance
Full RPL10A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All RPL10A variants
Uncertain significance 9
- p.Arg202Trp Single submitter ⚠
- p.Arg23His Single submitter ⚠
- p.Arg25His Single submitter ⚠
- p.Asn182Asp Single submitter ⚠
- p.Asn94Ser Single submitter ⚠
- p.Lys102Arg Single submitter ⚠
- p.Ser64Cys Single submitter ⚠
- p.Ser6Pro Single submitter ⚠
- p.Val148Met Single submitter ⚠