RPL18A — 23 ClinVar variants
All ClinVar germline RPL18A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
23 Uncertain significance
Full RPL18A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL18A p.Ala133Thr Uncertain significance Single submitter
- RPL18A p.Arg138Cys Uncertain significance Single submitter
- RPL18A p.Arg138His Uncertain significance Single submitter
- RPL18A p.Arg29Cys Uncertain significance Single submitter
- RPL18A p.Arg8Gln Uncertain significance Single submitter
- RPL18A p.Lys11Arg Uncertain significance Single submitter
- RPL18A p.Phe175Ile Uncertain significance Single submitter
- RPL18A p.Phe175Ser Uncertain significance Single submitter
- RPL18A p.Ser4Ala Uncertain significance Single submitter
- RPL18A p.Tyr97Cys Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- RPL18A p.Ala133Val Uncertain significance Single submitter
- RPL18A p.Ala3Val Uncertain significance Single submitter
- RPL18A p.Arg111Gln Uncertain significance Single submitter
- RPL18A p.Arg120Gln Uncertain significance Single submitter
- RPL18A p.Arg160Cys Uncertain significance Single submitter
- RPL18A p.Arg31Gln Uncertain significance Single submitter
- RPL18A p.Arg74Gln Uncertain significance Single submitter
- RPL18A p.Gly5Ser Uncertain significance Single submitter
- RPL18A p.Lys143Arg Uncertain significance Single submitter
- RPL18A p.Ser71Tyr Uncertain significance Single submitter
- RPL18A p.Thr24Arg Uncertain significance Single submitter
- RPL18A p.Thr24Met Uncertain significance Single submitter
All RPL18A variants
Uncertain significance 23
- p.Ala133Thr Single submitter ⚠
- p.Ala133Val Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Arg111Gln Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg138Cys Single submitter ⚠
- p.Arg138His Single submitter ⚠
- p.Arg160Cys Single submitter ⚠
- p.Arg161His Single submitter
- p.Arg29Cys Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Gly5Ser Single submitter ⚠
- p.Lys11Arg Single submitter ⚠
- p.Lys143Arg Single submitter ⚠
- p.Phe175Ile Single submitter ⚠
- p.Phe175Ser Single submitter ⚠
- p.Ser4Ala Single submitter ⚠
- p.Ser71Tyr Single submitter ⚠
- p.Thr24Arg Single submitter ⚠
- p.Thr24Met Single submitter ⚠
- p.Tyr97Cys Single submitter ⚠