RPL23A — 23 ClinVar variants
All ClinVar germline RPL23A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
23 Uncertain significance
Full RPL23A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL23A p.Ala21Pro Uncertain significance Single submitter
- RPL23A p.Ala65Thr Uncertain significance Single submitter
- RPL23A p.Ala86Ser Uncertain significance Single submitter
- RPL23A p.Arg41Leu Uncertain significance Single submitter
- RPL23A p.Arg67Lys Uncertain significance Single submitter
- RPL23A p.Asn105Lys Uncertain significance Single submitter
- RPL23A p.Asn94Thr Uncertain significance Single submitter
- RPL23A p.Asp131Val Uncertain significance Single submitter
- RPL23A p.Gly31Cys Uncertain significance Single submitter
- RPL23A p.Ile40Thr Uncertain significance Single submitter
- RPL23A p.Leu71Arg Uncertain significance Single submitter
- RPL23A p.Lys39Met Uncertain significance Single submitter
- RPL23A p.Lys59Thr Uncertain significance Single submitter
- RPL23A p.Pro10Ser Uncertain significance Single submitter
- RPL23A p.Pro12Ala Uncertain significance Single submitter
- RPL23A p.Pro12Ser Uncertain significance Single submitter
- RPL23A p.Pro58Ala Uncertain significance Single submitter
- RPL23A p.Pro61Leu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RPL23A variants
Uncertain significance 23
- p.Ala21Pro Single submitter ⚠
- p.Ala27Thr Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Ala86Ser Single submitter ⚠
- p.Arg41Leu Single submitter ⚠
- p.Arg67Lys Single submitter ⚠
- p.Asn105Lys Single submitter ⚠
- p.Asn94Thr Single submitter ⚠
- p.Asp131Asn Single submitter ⚠
- p.Asp131Val Single submitter ⚠
- p.Gly31Cys Single submitter ⚠
- p.Ile40Thr Single submitter ⚠
- p.Leu71Arg Single submitter ⚠
- p.Lys39Met Single submitter ⚠
- p.Lys59Thr Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro12Ala Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro58Ala Single submitter ⚠
- p.Pro61Leu Single submitter ⚠
- p.Thr42Ala Single submitter