RPL27A — 10 ClinVar variants
All ClinVar germline RPL27A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
10 Uncertain significance
Full RPL27A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All RPL27A variants
Uncertain significance 10
- p.Ala148Val Single submitter ⚠
- p.Ala98Ser Single submitter ⚠
- p.Arg87Gln Single submitter ⚠
- p.Arg87Trp Single submitter
- p.Asn74Ser Single submitter
- p.Asn93Ser Single submitter ⚠
- p.Gly96Val Single submitter ⚠
- p.Leu112Val Single submitter ⚠
- p.Lys119Glu Single submitter ⚠
- p.Pro121Ser Single submitter ⚠