RPL28 — 24 ClinVar variants
All ClinVar germline RPL28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
1 Benign · 1 Likely benign · 22 Uncertain significance
Full RPL28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL28 p.Ala86Thr Uncertain significance Single submitter
- RPL28 p.Arg11Gln Uncertain significance Single submitter
- RPL28 p.Arg11Trp Uncertain significance Single submitter
- RPL28 p.Arg98Cys Uncertain significance Single submitter
- RPL28 p.Arg98Gly Uncertain significance Single submitter
- RPL28 p.His45Arg Uncertain significance Single submitter
- RPL28 p.Thr48Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- RPL28 p.Arg71Gln Uncertain significance Single submitter
- RPL28 p.Asn36Ser Uncertain significance Single submitter
- RPL28 p.Cys13Gly Uncertain significance Single submitter
- RPL28 p.Pro53Ser Uncertain significance Single submitter
- RPL28 p.Ser68Cys Uncertain significance Single submitter
- RPL28 p.Ser91Asn Uncertain significance Single submitter
- RPL28 p.Thr81Ala Uncertain significance Single submitter
- RPL28 p.Thr81Asn Uncertain significance Single submitter
All RPL28 variants
Benign 1
- c.*3302T>C Multiple submitters
Likely benign 1
- c.*3333G>A Single submitter
Uncertain significance 22
- c.*3249C>T Single submitter
- c.*3273C>A Single submitter
- c.*3273C>T Single submitter
- c.*3306C>T Single submitter
- c.*3325T>C Single submitter
- c.*3327C>T Single submitter
- c.*3403C>A Single submitter
- p.Ala86Thr Single submitter ⚠
- p.Arg11Gln Single submitter ⚠
- p.Arg11Trp Single submitter ⚠
- p.Arg71Gln Single submitter ⚠
- p.Arg98Cys Single submitter ⚠
- p.Arg98Gly Single submitter ⚠
- p.Asn36Ser Single submitter ⚠
- p.Cys13Gly Single submitter ⚠
- p.His45Arg Single submitter ⚠
- p.Pro53Ser Single submitter ⚠
- p.Ser68Cys Single submitter ⚠
- p.Ser91Asn Single submitter ⚠
- p.Thr48Ile Single submitter ⚠
- p.Thr81Ala Single submitter ⚠
- p.Thr81Asn Single submitter ⚠