RPL3 — 58 ClinVar variants
All ClinVar germline RPL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
3 Benign · 3 Likely benign · 52 Uncertain significance
Full RPL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL3 p.Ala197Thr Uncertain significance Single submitter
- RPL3 p.Ala398Gly Uncertain significance Single submitter
- RPL3 p.Arg161His Uncertain significance Single submitter
- RPL3 p.Arg242His Uncertain significance Single submitter
- RPL3 p.Arg277Cys Uncertain significance Single submitter
- RPL3 p.Arg348Ser Uncertain significance Single submitter
- RPL3 p.Arg357Trp Uncertain significance Single submitter
- RPL3 p.Asn302Ser Uncertain significance Single submitter
- RPL3 p.Asp112Glu Uncertain significance Single submitter
- RPL3 p.Glu74Val Uncertain significance Single submitter
- RPL3 p.His322Gln Uncertain significance Single submitter
- RPL3 p.His322Tyr Uncertain significance Single submitter
- RPL3 p.Ile163Val Uncertain significance Single submitter
- RPL3 p.Ile280Val Uncertain significance Single submitter
- RPL3 p.Ile368Val Uncertain significance Single submitter
- RPL3 p.Leu352Pro Uncertain significance Single submitter
- RPL3 p.Lys120Glu Uncertain significance Single submitter
- RPL3 p.Lys135Glu Uncertain significance Single submitter
- RPL3 p.Lys334Glu Uncertain significance Single submitter
- RPL3 p.Met382Ile Uncertain significance Single submitter
- RPL3 p.Met389Arg Uncertain significance Single submitter
- RPL3 p.Phe118Cys Uncertain significance Single submitter
- RPL3 p.Phe118Tyr Uncertain significance Single submitter
- RPL3 p.Phe211Leu Uncertain significance Single submitter
- RPL3 p.Pro206Leu Uncertain significance Single submitter
- RPL3 p.Pro33Arg Uncertain significance Single submitter
- RPL3 p.Ser151Gly Uncertain significance Single submitter
- RPL3 p.Ser23Arg Uncertain significance Single submitter
- RPL3 p.Ser23Thr Uncertain significance Single submitter
- RPL3 p.Thr44Ala Uncertain significance Single submitter
- RPL3 p.Thr54Ser Uncertain significance Single submitter
- RPL3 p.Tyr285Cys Uncertain significance Single submitter
- RPL3 p.Val105Leu Uncertain significance Single submitter
- RPL3 p.Val205Ile Uncertain significance Single submitter
- RPL3 p.Val222Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- RPL3 p.Arg174His Uncertain significance Single submitter
- RPL3 p.Arg358Trp Uncertain significance Single submitter
- RPL3 p.Asn121Ser Uncertain significance Single submitter
- RPL3 p.Cys134Arg Uncertain significance Single submitter
- RPL3 p.Gln213His Uncertain significance Single submitter
- RPL3 p.Glu71Asp Uncertain significance Single submitter
- RPL3 p.Lys143Thr Uncertain significance Single submitter
- RPL3 p.Lys148Glu Uncertain significance Single submitter
- RPL3 p.Lys30Arg Uncertain significance Single submitter
- RPL3 p.Met168Ile Uncertain significance Single submitter
- RPL3 p.Pro37Leu Uncertain significance Single submitter
- RPL3 p.Val105Ala Uncertain significance Single submitter
All RPL3 variants
Benign 3
- p.Pro37= Multiple submitters
- c.197-13dup Single submitter
- c.366-70C>T Single submitter
Likely benign 3
- p.Ala398Thr Single submitter
- p.Arg249= Single submitter
- p.Met382Val Single submitter
Uncertain significance 52
- c.850-18_850-6del Single submitter
- p.Ala197Thr Single submitter ⚠
- p.Ala398Gly Single submitter ⚠
- p.Arg161His Single submitter ⚠
- p.Arg169Cys Single submitter
- p.Arg174His Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg277Cys Single submitter ⚠
- p.Arg348Ser Single submitter ⚠
- p.Arg357Trp Single submitter ⚠
- p.Arg358Trp Single submitter ⚠
- p.Asn121Ser Single submitter ⚠
- p.Asn302Ser Single submitter ⚠
- p.Asp112Glu Single submitter ⚠
- p.Cys134Arg Single submitter ⚠
- p.Gln213His Single submitter ⚠
- p.Glu71Asp Single submitter ⚠
- p.Glu74Val Single submitter ⚠
- p.His322Gln Single submitter ⚠
- p.His322Tyr Single submitter ⚠
- p.Ile163Val Single submitter ⚠
- p.Ile280Val Single submitter ⚠
- p.Ile368Val Single submitter ⚠
- p.Leu347Phe Single submitter
- p.Leu352Pro Single submitter ⚠
- p.Leu43Phe Single submitter
- p.Lys120Glu Single submitter ⚠
- p.Lys135Glu Single submitter ⚠
- p.Lys143Thr Single submitter ⚠
- p.Lys148Glu Single submitter ⚠
- p.Lys282Arg Single submitter
- p.Lys30Arg Single submitter ⚠
- p.Lys334Glu Single submitter ⚠
- p.Met168Ile Single submitter ⚠
- p.Met382Ile Single submitter ⚠
- p.Met389Arg Single submitter ⚠
- p.Phe118Cys Single submitter ⚠
- p.Phe118Tyr Single submitter ⚠
- p.Phe211Leu Single submitter ⚠
- p.Pro206Leu Single submitter ⚠
- p.Pro33Arg Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Ser151Gly Single submitter ⚠
- p.Ser23Arg Single submitter ⚠
- p.Ser23Thr Single submitter ⚠
- p.Thr44Ala Single submitter ⚠
- p.Thr54Ser Single submitter ⚠
- p.Tyr285Cys Single submitter ⚠
- p.Val105Ala Single submitter ⚠
- p.Val105Leu Single submitter ⚠
- p.Val205Ile Single submitter ⚠
- p.Val222Met Single submitter ⚠