RPL34 — 9 ClinVar variants
All ClinVar germline RPL34 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
2 Likely benign · 7 Uncertain significance
Full RPL34 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL34 p.Arg57His Uncertain significance Single submitter
- RPL34 p.Arg9His Uncertain significance Single submitter
- RPL34 p.Leu33Val Uncertain significance Single submitter
- RPL34 p.Thr6Pro Uncertain significance Single submitter
- RPL34 p.Tyr7Ser Uncertain significance Single submitter
- RPL34 p.Val56Ile Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All RPL34 variants
Uncertain significance 7
- p.Arg57His Single submitter ⚠
- p.Arg9His Single submitter ⚠
- p.Leu33Val Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Thr6Pro Single submitter ⚠
- p.Tyr7Ser Single submitter ⚠
- p.Val56Ile Single submitter ⚠