RPL37 — 8 ClinVar variants
All ClinVar germline RPL37 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
8 Uncertain significance
Full RPL37 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL37 p.Ala92Gly Uncertain significance Single submitter
- RPL37 p.His28Arg Uncertain significance Single submitter
- RPL37 p.Lys44Arg Uncertain significance Single submitter
- RPL37 p.Lys44Gln Uncertain significance Single submitter
- RPL37 p.Tyr71His Uncertain significance Single submitter
- RPL37 p.Val70Leu Uncertain significance Single submitter
All RPL37 variants
Uncertain significance 8
- p.Ala92Gly Single submitter ⚠
- p.Arg72His Single submitter
- p.His28Arg Single submitter ⚠
- p.His76Arg Single submitter
- p.Lys44Arg Single submitter ⚠
- p.Lys44Gln Single submitter ⚠
- p.Tyr71His Single submitter ⚠
- p.Val70Leu Single submitter ⚠