RPL4 — 45 ClinVar variants
All ClinVar germline RPL4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Likely benign · 43 Uncertain significance
Full RPL4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL4 p.Ala354Val Uncertain significance Single submitter
- RPL4 p.Ala359Val Uncertain significance Single submitter
- RPL4 p.Ala369Gly Uncertain significance Single submitter
- RPL4 p.Ala369Val Uncertain significance Single submitter
- RPL4 p.Ala408Val Uncertain significance Single submitter
- RPL4 p.Arg110Cys Uncertain significance Single submitter
- RPL4 p.Arg121Gln Uncertain significance Single submitter
-
RPL4 p.Arg204Leu
Uncertain significance
Single submitter
exstrophy-epispadias complex
- RPL4 p.Arg306Cys Uncertain significance Single submitter
- RPL4 p.Arg311Cys Uncertain significance Single submitter
- RPL4 p.Asn178Ser Uncertain significance Single submitter
- RPL4 p.Asp366Glu Uncertain significance Single submitter
- RPL4 p.Asp366His Uncertain significance Single submitter
- RPL4 p.Gln392Lys Uncertain significance Single submitter
- RPL4 p.Glu13Lys Uncertain significance Single submitter
- RPL4 p.Gly373Ser Uncertain significance Single submitter
- RPL4 p.Gly379Ser Uncertain significance Single submitter
- RPL4 p.His85Gln Uncertain significance Single submitter
- RPL4 p.Leu289Ile Uncertain significance Single submitter
- RPL4 p.Pro134Ser Uncertain significance Single submitter
- RPL4 p.Pro376Ala Uncertain significance Single submitter
- RPL4 p.Pro425Ser Uncertain significance Single submitter
- RPL4 p.Thr23Ser Uncertain significance Single submitter
- RPL4 p.Thr419Ala Uncertain significance Single submitter
- RPL4 p.Thr419Pro Uncertain significance Single submitter
- RPL4 p.Tyr161Phe Uncertain significance Single submitter
- RPL4 p.Val389Ile Uncertain significance Single submitter
-
RPL4 p.Arg143His
Uncertain significance
No assertion criteria
High myopia
Predictors split 15
The independent predictors disagree with each other — read with care.
- RPL4 p.Ala304Thr Uncertain significance Single submitter
- RPL4 p.Ala355Pro Uncertain significance Single submitter
- RPL4 p.Ala357Gly Uncertain significance Single submitter
- RPL4 p.Ile309Met Uncertain significance Single submitter
- RPL4 p.Lys163Arg Uncertain significance Single submitter
- RPL4 p.Lys181Thr Uncertain significance Single submitter
- RPL4 p.Lys308Asn Uncertain significance Single submitter
- RPL4 p.Lys333Gln Uncertain significance Single submitter
- RPL4 p.Lys348Asn Uncertain significance Single submitter
- RPL4 p.Lys394Gln Uncertain significance Single submitter
- RPL4 p.Lys411Arg Uncertain significance Single submitter
- RPL4 p.Lys412Asn Uncertain significance Single submitter
- RPL4 p.Lys423Arg Uncertain significance Single submitter
- RPL4 p.Pro425Leu Uncertain significance Single submitter
- RPL4 p.Val313Ala Uncertain significance Single submitter
All RPL4 variants
Uncertain significance 43
- p.Ala304Thr Single submitter ⚠
- p.Ala354Val Single submitter ⚠
- p.Ala355Pro Single submitter ⚠
- p.Ala357Gly Single submitter ⚠
- p.Ala359Val Single submitter ⚠
- p.Ala369Gly Single submitter ⚠
- p.Ala369Val Single submitter ⚠
- p.Ala408Val Single submitter ⚠
- p.Arg110Cys Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg204Leu Single submitter exstrophy-epispadias complex ⚠
- p.Arg306Cys Single submitter ⚠
- p.Arg311Cys Single submitter ⚠
- p.Asn178Ser Single submitter ⚠
- p.Asp366Glu Single submitter ⚠
- p.Asp366His Single submitter ⚠
- p.Gln392Lys Single submitter ⚠
- p.Glu13Lys Single submitter ⚠
- p.Gly373Ser Single submitter ⚠
- p.Gly379Ser Single submitter ⚠
- p.His85Gln Single submitter ⚠
- p.Ile309Met Single submitter ⚠
- p.Leu289Ile Single submitter ⚠
- p.Lys163Arg Single submitter ⚠
- p.Lys181Thr Single submitter ⚠
- p.Lys308Asn Single submitter ⚠
- p.Lys333Gln Single submitter ⚠
- p.Lys348Asn Single submitter ⚠
- p.Lys394Gln Single submitter ⚠
- p.Lys411Arg Single submitter ⚠
- p.Lys412Asn Single submitter ⚠
- p.Lys423Arg Single submitter ⚠
- p.Pro134Ser Single submitter ⚠
- p.Pro376Ala Single submitter ⚠
- p.Pro425Leu Single submitter ⚠
- p.Pro425Ser Single submitter ⚠
- p.Thr23Ser Single submitter ⚠
- p.Thr419Ala Single submitter ⚠
- p.Thr419Pro Single submitter ⚠
- p.Tyr161Phe Single submitter ⚠
- p.Val313Ala Single submitter ⚠
- p.Val389Ile Single submitter ⚠
- p.Arg143His No assertion criteria High myopia ⚠