RPL6 — 35 ClinVar variants
All ClinVar germline RPL6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Likely benign · 34 Uncertain significance
Full RPL6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL6 p.Ala169Val Uncertain significance Single submitter
- RPL6 p.Arg156Cys Uncertain significance Single submitter
- RPL6 p.Arg223Gln Uncertain significance Single submitter
- RPL6 p.Arg246His Uncertain significance Single submitter
- RPL6 p.Gln135Arg Uncertain significance Single submitter
- RPL6 p.Glu13Lys Uncertain significance Single submitter
- RPL6 p.Ile248Met Uncertain significance Single submitter
- RPL6 p.Ile257Leu Uncertain significance Single submitter
- RPL6 p.Leu174Phe Uncertain significance Single submitter
- RPL6 p.Lys28Gln Uncertain significance Single submitter
- RPL6 p.Phe217Leu Uncertain significance Single submitter
- RPL6 p.Pro117Ser Uncertain significance Single submitter
- RPL6 p.Thr11Ile Uncertain significance Single submitter
- RPL6 p.Tyr115His Uncertain significance Single submitter
- RPL6 p.Tyr216Cys Uncertain significance Single submitter
- RPL6 p.Val274Met Uncertain significance Single submitter
- RPL6 p.Val80Phe Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- RPL6 p.Arg110His Uncertain significance Single submitter
- RPL6 p.Arg123Gly Uncertain significance Single submitter
- RPL6 p.Arg158Gly Uncertain significance Single submitter
- RPL6 p.Arg158Lys Uncertain significance Single submitter
- RPL6 p.Arg183Gln Uncertain significance Single submitter
- RPL6 p.Arg56Thr Uncertain significance Single submitter
- RPL6 p.Gln268Pro Uncertain significance Single submitter
- RPL6 p.Gly103Ser Uncertain significance Single submitter
- RPL6 p.Gly129Ser Uncertain significance Single submitter
- RPL6 p.Leu222Gln Uncertain significance Single submitter
- RPL6 p.Lys20Asn Uncertain significance Single submitter
- RPL6 p.Lys262Thr Uncertain significance Single submitter
- RPL6 p.Met112Ile Uncertain significance Single submitter
- RPL6 p.Pro122Leu Uncertain significance Single submitter
- RPL6 p.Pro16Arg Uncertain significance Single submitter
- RPL6 p.Thr278Met Uncertain significance Single submitter
- RPL6 p.Thr93Arg Uncertain significance Single submitter
All RPL6 variants
Likely benign 1
- p.His128= Single submitter
Uncertain significance 34
- p.Ala169Val Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg123Gly Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg158Gly Single submitter ⚠
- p.Arg158Lys Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg223Gln Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg56Thr Single submitter ⚠
- p.Gln135Arg Single submitter ⚠
- p.Gln268Pro Single submitter ⚠
- p.Glu13Lys Single submitter ⚠
- p.Gly103Ser Single submitter ⚠
- p.Gly129Ser Single submitter ⚠
- p.Ile248Met Single submitter ⚠
- p.Ile257Leu Single submitter ⚠
- p.Leu174Phe Single submitter ⚠
- p.Leu222Gln Single submitter ⚠
- p.Lys20Asn Single submitter ⚠
- p.Lys262Thr Single submitter ⚠
- p.Lys28Gln Single submitter ⚠
- p.Met112Ile Single submitter ⚠
- p.Phe217Leu Single submitter ⚠
- p.Pro117Ser Single submitter ⚠
- p.Pro122Leu Single submitter ⚠
- p.Pro16Arg Single submitter ⚠
- p.Thr11Ile Single submitter ⚠
- p.Thr278Met Single submitter ⚠
- p.Thr93Arg Single submitter ⚠
- p.Tyr115His Single submitter ⚠
- p.Tyr216Cys Single submitter ⚠
- p.Val274Met Single submitter ⚠
- p.Val80Phe Single submitter ⚠