RPL7 — 39 ClinVar variants
All ClinVar germline RPL7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
2 Likely benign · 37 Uncertain significance
Full RPL7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPL7 p.Arg177Gln Uncertain significance Single submitter
- RPL7 p.Arg200His Uncertain significance Single submitter
- RPL7 p.Arg47Gly Uncertain significance Single submitter
- RPL7 p.Arg70Leu Uncertain significance Single submitter
- RPL7 p.His56Gln Uncertain significance Single submitter
- RPL7 p.Ile185Val Uncertain significance Single submitter
- RPL7 p.Ile98Val Uncertain significance Single submitter
- RPL7 p.Lys36Asn Uncertain significance Single submitter
- RPL7 p.Pro15Leu Uncertain significance Single submitter
- RPL7 p.Pro87Ala Uncertain significance Single submitter
- RPL7 p.Ser129Leu Uncertain significance Single submitter
- RPL7 p.Ser178Cys Uncertain significance Single submitter
- RPL7 p.Val101Ala Uncertain significance Single submitter
- RPL7 p.Val150Ala Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- RPL7 p.Arg23Thr Uncertain significance Single submitter
- RPL7 p.Arg46Lys Uncertain significance Single submitter
- RPL7 p.Asn119Ser Uncertain significance Single submitter
- RPL7 p.Asn146Thr Uncertain significance Single submitter
- RPL7 p.Asn163Ser Uncertain significance Single submitter
- RPL7 p.Gly3Arg Uncertain significance Single submitter
- RPL7 p.Ile244Leu Uncertain significance Single submitter
- RPL7 p.Ile30Met Uncertain significance Single submitter
- RPL7 p.Ile50Met Uncertain significance Single submitter
- RPL7 p.Leu125Phe Uncertain significance Single submitter
- RPL7 p.Leu147Val Uncertain significance Single submitter
- RPL7 p.Leu18Val Uncertain significance Single submitter
- RPL7 p.Lys127Arg Uncertain significance Single submitter
- RPL7 p.Lys48Arg Uncertain significance Single submitter
- RPL7 p.Lys55Asn Uncertain significance Single submitter
- RPL7 p.Lys55Glu Uncertain significance Single submitter
- RPL7 p.Met41Arg Uncertain significance Single submitter
- RPL7 p.Met41Thr Uncertain significance Single submitter
- RPL7 p.Met64Ile Uncertain significance Single submitter
- RPL7 p.Pro12Thr Uncertain significance Single submitter
- RPL7 p.Tyr82Cys Uncertain significance Single submitter
All RPL7 variants
Uncertain significance 37
- p.Arg177Gln Single submitter ⚠
- p.Arg200His Single submitter ⚠
- p.Arg23Thr Single submitter ⚠
- p.Arg46Lys Single submitter ⚠
- p.Arg47Gly Single submitter ⚠
- p.Arg70Leu Single submitter ⚠
- p.Asn119Ser Single submitter ⚠
- p.Asn146Thr Single submitter ⚠
- p.Asn163Ser Single submitter ⚠
- p.Gly3Arg Single submitter ⚠
- p.His56Gln Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Ile244Leu Single submitter ⚠
- p.Ile30Met Single submitter ⚠
- p.Ile50Met Single submitter ⚠
- p.Ile98Val Single submitter ⚠
- p.Leu125Phe Single submitter ⚠
- p.Leu147Val Single submitter ⚠
- p.Leu18Val Single submitter ⚠
- p.Lys127Arg Single submitter ⚠
- p.Lys36Asn Single submitter ⚠
- p.Lys48Arg Single submitter ⚠
- p.Lys55Asn Single submitter ⚠
- p.Lys55Glu Single submitter ⚠
- p.Met41Arg Single submitter ⚠
- p.Met41Thr Single submitter ⚠
- p.Met64Ile Single submitter ⚠
- p.Pro12Thr Single submitter ⚠
- p.Pro15Leu Single submitter ⚠
- p.Pro87Ala Single submitter ⚠
- p.Ser129Leu Single submitter ⚠
- p.Ser178Cys Single submitter ⚠
- p.Tyr51His Single submitter
- p.Tyr82Cys Single submitter ⚠
- p.Val101Ala Single submitter ⚠
- p.Val14Met Single submitter
- p.Val150Ala Single submitter ⚠