RPLP0 — 38 ClinVar variants
All ClinVar germline RPLP0 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Benign · 37 Uncertain significance
Full RPLP0 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPLP0 p.Ala288Asp Uncertain significance Single submitter
- RPLP0 p.Ala292Val Uncertain significance Single submitter
- RPLP0 p.Asn179Ser Uncertain significance Single submitter
- RPLP0 p.Asn200Ser Uncertain significance Single submitter
- RPLP0 p.Asp205His Uncertain significance Single submitter
- RPLP0 p.Gln39Glu Uncertain significance Single submitter
- RPLP0 p.Glu305Gln Uncertain significance Single submitter
- RPLP0 p.Gly164Ala Uncertain significance Single submitter
- RPLP0 p.Gly196Ala Uncertain significance Single submitter
- RPLP0 p.Leu103Pro Uncertain significance Single submitter
- RPLP0 p.Leu211Gln Uncertain significance Single submitter
- RPLP0 p.Met101Ile Uncertain significance Single submitter
- RPLP0 p.Met177Thr Uncertain significance Single submitter
- RPLP0 p.Pro182Ser Uncertain significance Single submitter
- RPLP0 p.Pro238Leu Uncertain significance Single submitter
- RPLP0 p.Pro289Ala Uncertain significance Single submitter
- RPLP0 p.Ser148Phe Uncertain significance Single submitter
- RPLP0 p.Ser307Leu Uncertain significance Single submitter
- RPLP0 p.Thr59Pro Uncertain significance Single submitter
- RPLP0 p.Tyr199Cys Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- RPLP0 p.Ala291Gly Uncertain significance Single submitter
- RPLP0 p.Arg214His Uncertain significance Single submitter
- RPLP0 p.Arg220Cys Uncertain significance Single submitter
- RPLP0 p.Arg220His Uncertain significance Single submitter
- RPLP0 p.Arg220Ser Uncertain significance Single submitter
- RPLP0 p.Arg247Gln Uncertain significance Single submitter
- RPLP0 p.Asn12Ser Uncertain significance Single submitter
- RPLP0 p.Asn243Ser Uncertain significance Single submitter
- RPLP0 p.Gln191His Uncertain significance Single submitter
- RPLP0 p.Glu306Asp Uncertain significance Single submitter
- RPLP0 p.Glu309Gln Uncertain significance Single submitter
- RPLP0 p.Ile116Thr Uncertain significance Single submitter
- RPLP0 p.Lys57Arg Uncertain significance Single submitter
- RPLP0 p.Thr255Met Uncertain significance Single submitter
- RPLP0 p.Thr286Ile Uncertain significance Single submitter
All RPLP0 variants
Benign 1
- p.Lys92= Multiple submitters
Uncertain significance 37
- p.Ala288Asp Single submitter ⚠
- p.Ala291Gly Single submitter ⚠
- p.Ala292Val Single submitter ⚠
- p.Arg214His Single submitter ⚠
- p.Arg220Cys Single submitter ⚠
- p.Arg220His Single submitter ⚠
- p.Arg220Ser Single submitter ⚠
- p.Arg247Gln Single submitter ⚠
- p.Asn12Ser Single submitter ⚠
- p.Asn179Ser Single submitter ⚠
- p.Asn200Ser Single submitter ⚠
- p.Asn243Ser Single submitter ⚠
- p.Asp205His Single submitter ⚠
- p.Gln191His Single submitter ⚠
- p.Gln39Glu Single submitter ⚠
- p.Glu305Gln Single submitter ⚠
- p.Glu306Asp Single submitter ⚠
- p.Glu309Gln Single submitter ⚠
- p.Gly164Ala Single submitter ⚠
- p.Gly196Ala Single submitter ⚠
- p.Ile116Thr Single submitter ⚠
- p.Leu103Pro Single submitter ⚠
- p.Leu211Gln Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Met101Ile Single submitter ⚠
- p.Met177Thr Single submitter ⚠
- p.Pro182Ser Single submitter ⚠
- p.Pro238Leu Single submitter ⚠
- p.Pro289Ala Single submitter ⚠
- p.Ser148Phe Single submitter ⚠
- p.Ser304Leu Single submitter
- p.Ser307Leu Single submitter ⚠
- p.Thr233Ala Single submitter
- p.Thr255Met Single submitter ⚠
- p.Thr286Ile Single submitter ⚠
- p.Thr59Pro Single submitter ⚠
- p.Tyr199Cys Single submitter ⚠