RPLP1 — 13 ClinVar variants
All ClinVar germline RPLP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
13 Uncertain significance
Full RPLP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPLP1 p.Asp106Asn Uncertain significance Single submitter
- RPLP1 p.Asp107Asn Uncertain significance Single submitter
- RPLP1 p.Gly66Arg Uncertain significance Single submitter
- RPLP1 p.Ile28Met Uncertain significance Single submitter
- RPLP1 p.Ile56Thr Uncertain significance Single submitter
- RPLP1 p.Pro88Ser Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- RPLP1 p.Asn53Lys Uncertain significance Single submitter
- RPLP1 p.Asn53Ser Uncertain significance Single submitter
- RPLP1 p.Asn62Ser Uncertain significance Single submitter
- RPLP1 p.Gly66Ser Uncertain significance Single submitter
- RPLP1 p.Gly73Asp Uncertain significance Single submitter
- RPLP1 p.Ser83Phe Uncertain significance Single submitter
- RPLP1 p.Val54Ile Uncertain significance Single submitter
All RPLP1 variants
Uncertain significance 13
- p.Asn53Lys Single submitter ⚠
- p.Asn53Ser Single submitter ⚠
- p.Asn62Ser Single submitter ⚠
- p.Asp106Asn Single submitter ⚠
- p.Asp107Asn Single submitter ⚠
- p.Gly66Arg Single submitter ⚠
- p.Gly66Ser Single submitter ⚠
- p.Gly73Asp Single submitter ⚠
- p.Ile28Met Single submitter ⚠
- p.Ile56Thr Single submitter ⚠
- p.Pro88Ser Single submitter ⚠
- p.Ser83Phe Single submitter ⚠
- p.Val54Ile Single submitter ⚠