RPLP2 — 18 ClinVar variants
All ClinVar germline RPLP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
18 Uncertain significance
Full RPLP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPLP2 p.Ala87Val Uncertain significance Single submitter
- RPLP2 p.Asp106Asn Uncertain significance Single submitter
- RPLP2 p.Asp36His Uncertain significance Single submitter
- RPLP2 p.Glu93Lys Uncertain significance Single submitter
- RPLP2 p.Gly68Val Uncertain significance Single submitter
- RPLP2 p.Ile59Thr Uncertain significance Single submitter
- RPLP2 p.Lys21Arg Uncertain significance Single submitter
- RPLP2 p.Lys99Glu Uncertain significance Single submitter
- RPLP2 p.Pro82Ser Uncertain significance Single submitter
- RPLP2 p.Pro88Ala Uncertain significance Single submitter
- RPLP2 p.Ser29Asn Uncertain significance Single submitter
- RPLP2 p.Ser29Cys Uncertain significance Single submitter
- RPLP2 p.Ser64Ile Uncertain significance Single submitter
- RPLP2 p.Val54Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RPLP2 variants
Uncertain significance 18
- p.Ala70Thr Single submitter ⚠
- p.Ala87Pro Single submitter ⚠
- p.Ala87Val Single submitter ⚠
- p.Asp106Asn Single submitter ⚠
- p.Asp36His Single submitter ⚠
- p.Glu93Lys Single submitter ⚠
- p.Gly68Val Single submitter ⚠
- p.Ile59Thr Single submitter ⚠
- p.Leu62Phe Single submitter ⚠
- p.Lys21Arg Single submitter ⚠
- p.Lys99Glu Single submitter ⚠
- p.Pro82Ser Single submitter ⚠
- p.Pro88Ala Single submitter ⚠
- p.Ser19Ile Single submitter ⚠
- p.Ser29Asn Single submitter ⚠
- p.Ser29Cys Single submitter ⚠
- p.Ser64Ile Single submitter ⚠
- p.Val54Ala Single submitter ⚠