RPS11 — 15 ClinVar variants
All ClinVar germline RPS11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
4 Likely benign · 11 Uncertain significance
Full RPS11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS11 p.Ala149Thr Uncertain significance Single submitter
- RPS11 p.Arg89Cys Uncertain significance Single submitter
- RPS11 p.Ile4Val Uncertain significance Single submitter
- RPS11 p.Ile96Val Uncertain significance Single submitter
- RPS11 p.Lys107Glu Uncertain significance Single submitter
- RPS11 p.Lys79Gln Uncertain significance Single submitter
- RPS11 p.Ser114Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RPS11 variants
Likely benign 4
- c.224-8G>A Single submitter
- c.353+7G>A Single submitter
- p.Arg71= Single submitter
- p.Val111= Single submitter
Uncertain significance 11
- p.Ala149Thr Single submitter ⚠
- p.Arg84Lys Single submitter ⚠
- p.Arg89Cys Single submitter ⚠
- p.Ile4Val Single submitter ⚠
- p.Ile96Val Single submitter ⚠
- p.Lys107Glu Single submitter ⚠
- p.Lys79Gln Single submitter ⚠
- p.Met109Val Single submitter ⚠
- p.Ser114Ala Single submitter ⚠
- p.Thr78Ile Single submitter ⚠
- p.Val128Ala Single submitter ⚠