RPS16 — 11 ClinVar variants
All ClinVar germline RPS16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
1 Benign · 10 Uncertain significance
Full RPS16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS16 p.Arg138His Uncertain significance Single submitter
- RPS16 p.Gly59Ser Uncertain significance Single submitter
- RPS16 p.Lys17Asn Uncertain significance Single submitter
- RPS16 p.Lys4Arg Uncertain significance Single submitter
- RPS16 p.Ser129Ala Uncertain significance Single submitter
- RPS16 p.Val10Gly Uncertain significance Single submitter
- RPS16 p.Val55Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All RPS16 variants
Benign 1
- p.Asp123= Multiple submitters
Uncertain significance 10
- p.Arg138His Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Glu40Gly Single submitter
- p.Gly59Ser Single submitter ⚠
- p.Ile84Leu Single submitter
- p.Lys17Asn Single submitter ⚠
- p.Lys4Arg Single submitter ⚠
- p.Ser129Ala Single submitter ⚠
- p.Val10Gly Single submitter ⚠
- p.Val55Leu Single submitter ⚠