RPS2 — 23 ClinVar variants
All ClinVar germline RPS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
2 Benign · 2 Likely benign · 19 Uncertain significance
Full RPS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS2 p.Ala198Ser Uncertain significance Single submitter
- RPS2 p.Ala5Gly Uncertain significance Single submitter
- RPS2 p.Ala8Pro Uncertain significance Single submitter
- RPS2 p.Ala8Val Uncertain significance Single submitter
- RPS2 p.Arg167Gly Uncertain significance Single submitter
- RPS2 p.Arg284Trp Uncertain significance Single submitter
- RPS2 p.Asp220Glu Uncertain significance Single submitter
- RPS2 p.Gly153Glu Uncertain significance Single submitter
- RPS2 p.Ile33Ser Uncertain significance Single submitter
- RPS2 p.Pro164Arg Uncertain significance Single submitter
- RPS2 p.Ser77Phe Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- RPS2 p.Ala291Thr Uncertain significance Single submitter
- RPS2 p.Arg187His Uncertain significance Single submitter
- RPS2 p.Asn134Asp Uncertain significance Single submitter
- RPS2 p.Glu105Asp Uncertain significance Single submitter
- RPS2 p.Glu258Lys Uncertain significance Single submitter
- RPS2 p.Pro11Leu Uncertain significance Single submitter
- RPS2 p.Pro11Thr Uncertain significance Single submitter
- RPS2 p.Val274Ile Uncertain significance Single submitter
All RPS2 variants
Likely benign 2
- p.Gly37= Single submitter
- p.Met61Leu Single submitter
Uncertain significance 19
- p.Ala198Ser Single submitter ⚠
- p.Ala291Thr Single submitter ⚠
- p.Ala5Gly Single submitter ⚠
- p.Ala8Pro Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg167Gly Single submitter ⚠
- p.Arg187His Single submitter ⚠
- p.Arg284Trp Single submitter ⚠
- p.Asn134Asp Single submitter ⚠
- p.Asp220Glu Single submitter ⚠
- p.Glu105Asp Single submitter ⚠
- p.Glu258Lys Single submitter ⚠
- p.Gly153Glu Single submitter ⚠
- p.Ile33Ser Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro11Thr Single submitter ⚠
- p.Pro164Arg Single submitter ⚠
- p.Ser77Phe Single submitter ⚠
- p.Val274Ile Single submitter ⚠