RPS25 — 4 ClinVar variants
All ClinVar germline RPS25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
1 Benign · 3 Uncertain significance
Full RPS25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All RPS25 variants
Benign 1
- p.Thr110= Multiple submitters
Uncertain significance 3
- p.Ala118Gly Single submitter ⚠
- p.Ile97Thr Single submitter ⚠
- p.Pro3Leu Single submitter ⚠