RPS3 — 7 ClinVar variants
All ClinVar germline RPS3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 5 flagged for review →
1 Benign · 1 Likely benign · 5 Uncertain significance
Full RPS3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 5
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All RPS3 variants
Benign 1
- c.162-3C>T Multiple submitters
Likely benign 1
- p.Arg54= Single submitter
Uncertain significance 5
- p.Met189Val Single submitter ⚠
- p.Phe77Cys Single submitter ⚠
- p.Pro233Leu Single submitter ⚠
- p.Pro237Ser Single submitter ⚠
- p.Tyr34Cys Single submitter ⚠