RPS3A — 11 ClinVar variants
All ClinVar germline RPS3A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
11 Uncertain significance
Full RPS3A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS3A p.Arg162Cys Uncertain significance Single submitter
- RPS3A p.Asn186Ser Uncertain significance Single submitter
- RPS3A p.Ile44Val Uncertain significance Single submitter
- RPS3A p.Lys167Met Uncertain significance Single submitter
- RPS3A p.Lys195Arg Uncertain significance Single submitter
- RPS3A p.Thr246Lys Uncertain significance Single submitter
- RPS3A p.Val125Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All RPS3A variants
Uncertain significance 11
- p.Arg162Cys Single submitter ⚠
- p.Arg252Gln Single submitter ⚠
- p.Asn186Ser Single submitter ⚠
- p.Glu262Gly Single submitter
- p.Ile197Val Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Lys128Arg Single submitter ⚠
- p.Lys167Met Single submitter ⚠
- p.Lys195Arg Single submitter ⚠
- p.Thr246Lys Single submitter ⚠
- p.Val125Ile Single submitter ⚠