RPS4X — 14 ClinVar variants
All ClinVar germline RPS4X variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
1 Benign · 13 Uncertain significance
Full RPS4X gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS4X p.Arg145His Uncertain significance Single submitter
- RPS4X p.Arg3Cys Uncertain significance Single submitter
- RPS4X p.Arg68Gln Uncertain significance Single submitter
- RPS4X p.Leu38Val Uncertain significance Single submitter
- RPS4X p.Leu42Phe Uncertain significance Single submitter
- RPS4X p.Phe175Leu Uncertain significance Single submitter
- RPS4X p.Thr57Ala Uncertain significance Single submitter
- RPS4X p.Tyr103Cys Uncertain significance Single submitter
- RPS4X p.Val131Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RPS4X variants
Benign 1
- c.82-7G>T Multiple submitters
Uncertain significance 13
- p.Arg145His Single submitter ⚠
- p.Arg200Lys Single submitter ⚠
- p.Arg3Cys Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Ile162Leu Single submitter ⚠
- p.Leu38Val Single submitter ⚠
- p.Leu42Phe Single submitter ⚠
- p.Lys53Gln Single submitter ⚠
- p.Phe130Leu Single submitter ⚠
- p.Phe175Leu Single submitter ⚠
- p.Thr57Ala Single submitter ⚠
- p.Tyr103Cys Single submitter ⚠
- p.Val131Ala Single submitter ⚠