RPS5 — 11 ClinVar variants
All ClinVar germline RPS5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
11 Uncertain significance
Full RPS5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS5 p.Arg159His Uncertain significance Single submitter
- RPS5 p.Arg159Ser Uncertain significance Single submitter
- RPS5 p.Arg81Cys Uncertain significance Single submitter
- RPS5 p.Asp175Tyr Uncertain significance Single submitter
- RPS5 p.Ile169Thr Uncertain significance Single submitter
- RPS5 p.Pro50Ser Uncertain significance Single submitter
- RPS5 p.Tyr188Cys Uncertain significance Single submitter
- RPS5 p.Tyr188Phe Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All RPS5 variants
Uncertain significance 11
- p.Arg159His Single submitter ⚠
- p.Arg159Ser Single submitter ⚠
- p.Arg81Cys Single submitter ⚠
- p.Asp175Tyr Single submitter ⚠
- p.Ile169Thr Single submitter ⚠
- p.Ile92Val Single submitter
- p.Met76Val Single submitter ⚠
- p.Pro50Ser Single submitter ⚠
- p.Tyr188Cys Single submitter ⚠
- p.Tyr188Phe Single submitter ⚠
- p.Val11Gly Single submitter ⚠