RPS6KA6 — 47 ClinVar variants
All ClinVar germline RPS6KA6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Benign · 4 Likely benign · 41 Uncertain significance
Full RPS6KA6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS6KA6 p.Ala5Thr Uncertain significance Single submitter
- RPS6KA6 p.Ala71Thr Uncertain significance Single submitter
- RPS6KA6 p.Arg248Lys Uncertain significance Single submitter
- RPS6KA6 p.Arg636Pro Uncertain significance Single submitter
- RPS6KA6 p.Glu16Lys Uncertain significance Single submitter
- RPS6KA6 p.Glu397Lys Uncertain significance Single submitter
- RPS6KA6 p.Glu42Val Uncertain significance Single submitter
- RPS6KA6 p.Gly30Arg Uncertain significance Single submitter
- RPS6KA6 p.Gly41Glu Uncertain significance Single submitter
- RPS6KA6 p.His662Arg Uncertain significance Single submitter
- RPS6KA6 p.Ile412Val Uncertain significance Single submitter
- RPS6KA6 p.Ile415Val Uncertain significance Single submitter
- RPS6KA6 p.Ile468Val Uncertain significance Single submitter
- RPS6KA6 p.Ile523Met Uncertain significance Single submitter
- RPS6KA6 p.Ile561Val Uncertain significance Single submitter
- RPS6KA6 p.Ile57Val Uncertain significance Single submitter
- RPS6KA6 p.Lys459Arg Uncertain significance Single submitter
- RPS6KA6 p.Met737Val Uncertain significance Single submitter
- RPS6KA6 p.Phe170Leu Uncertain significance Single submitter
- RPS6KA6 p.Pro10Ser Uncertain significance Single submitter
- RPS6KA6 p.Pro403Ser Uncertain significance Single submitter
- RPS6KA6 p.Pro725Thr Uncertain significance Single submitter
- RPS6KA6 p.Ser111Cys Uncertain significance Single submitter
- RPS6KA6 p.Thr393Ala Uncertain significance Single submitter
- RPS6KA6 p.Thr402Ile Uncertain significance Single submitter
- RPS6KA6 p.Thr497Met Uncertain significance Single submitter
- RPS6KA6 p.Thr684Ile Uncertain significance Single submitter
- RPS6KA6 p.Val224Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- RPS6KA6 p.Arg508His Uncertain significance Single submitter
- RPS6KA6 p.Arg518Trp Uncertain significance Single submitter
- RPS6KA6 p.Gly374Ser Uncertain significance Single submitter
- RPS6KA6 p.Ile549Met Uncertain significance Single submitter
- RPS6KA6 p.Ile683Met Uncertain significance Single submitter
- RPS6KA6 p.Lys461Asn Uncertain significance Single submitter
- RPS6KA6 p.Lys501Asn Uncertain significance Single submitter
- RPS6KA6 p.Met615Val Uncertain significance Single submitter
- RPS6KA6 p.Phe642Leu Uncertain significance Single submitter
- RPS6KA6 p.Ser111Tyr Uncertain significance Single submitter
- RPS6KA6 p.Ser436Thr Uncertain significance Single submitter
- RPS6KA6 p.Tyr533Cys Uncertain significance Single submitter
All RPS6KA6 variants
Benign 2
- p.Asp692Asn Multiple submitters
- p.Leu179= Multiple submitters
Likely benign 4
- p.Met707Val Multiple submitters
- p.Phe4= Single submitter
- p.Val87= Single submitter
- p.Ala241Thr No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 41
- p.Ala180Ser Single submitter
- p.Ala5Thr Single submitter ⚠
- p.Ala71Thr Single submitter ⚠
- p.Arg248Lys Single submitter ⚠
- p.Arg508His Single submitter ⚠
- p.Arg518Trp Single submitter ⚠
- p.Arg636Pro Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu397Lys Single submitter ⚠
- p.Glu42Val Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly374Ser Single submitter ⚠
- p.Gly41Glu Single submitter ⚠
- p.His662Arg Single submitter ⚠
- p.Ile412Val Single submitter ⚠
- p.Ile415Val Single submitter ⚠
- p.Ile468Val Single submitter ⚠
- p.Ile523Met Single submitter ⚠
- p.Ile549Met Single submitter ⚠
- p.Ile561Val Single submitter ⚠
- p.Ile57Val Single submitter ⚠
- p.Ile683Met Single submitter ⚠
- p.Lys459Arg Single submitter ⚠
- p.Lys461Asn Single submitter ⚠
- p.Lys501Asn Single submitter ⚠
- p.Met615Val Single submitter ⚠
- p.Met737Val Single submitter ⚠
- p.Phe170Leu Single submitter ⚠
- p.Phe642Leu Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro403Ser Single submitter ⚠
- p.Pro725Thr Single submitter ⚠
- p.Ser111Cys Single submitter ⚠
- p.Ser111Tyr Single submitter ⚠
- p.Ser436Thr Single submitter ⚠
- p.Thr393Ala Single submitter ⚠
- p.Thr402Ile Single submitter ⚠
- p.Thr497Met Single submitter ⚠
- p.Thr684Ile Single submitter ⚠
- p.Tyr533Cys Single submitter ⚠
- p.Val224Ile Single submitter ⚠