RPS9 — 16 ClinVar variants
All ClinVar germline RPS9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
2 Benign · 1 Likely benign · 13 Uncertain significance
Full RPS9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RPS9 p.Arg109His Uncertain significance Single submitter
- RPS9 p.Arg162Cys Uncertain significance Single submitter
- RPS9 p.Arg172Cys Uncertain significance Single submitter
- RPS9 p.Arg80Trp Uncertain significance Single submitter
- RPS9 p.Asp190Gly Uncertain significance Single submitter
- RPS9 p.Glu193Asp Uncertain significance Single submitter
- RPS9 p.Gly181Val Uncertain significance Single submitter
- RPS9 p.Ile84Val Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All RPS9 variants
Benign 2
Likely benign 1
- p.Gly166= Single submitter
Uncertain significance 13
- p.Arg109His Single submitter ⚠
- p.Arg162Cys Single submitter ⚠
- p.Arg172Cys Single submitter ⚠
- p.Arg54Leu Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Asp158Asn Single submitter ⚠
- p.Asp190Gly Single submitter ⚠
- p.Glu193Asp Single submitter ⚠
- p.Gly181Val Single submitter ⚠
- p.Ile148Thr Single submitter ⚠
- p.Ile157Val Single submitter ⚠
- p.Ile84Val Single submitter ⚠
- p.Thr49Ile Single submitter ⚠