RRAS — 351 ClinVar variants
All ClinVar germline RRAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 155 flagged for review →
13 Conflicting · 8 Benign · 21 Benign/Likely benign · 123 Likely benign · 186 Uncertain significance
Full RRAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 155
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 6
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
RRAS p.Ala205Thr
Conflicting
Single submitter
Noonan syndrome
-
RRAS p.Ala77Thr
Conflicting
Single submitter
Noonan syndrome
-
RRAS p.Gly161Ser
Conflicting
Single submitter
Noonan syndrome
-
RRAS p.Leu217Val
Conflicting
Single submitter
Noonan syndrome
-
RRAS p.Val137Ile
Conflicting
Single submitter
Noonan syndrome
-
RRAS p.Val190Leu
Conflicting
Single submitter
Noonan syndrome
Predictors lean, ClinVar uncertain 132
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
RRAS p.Ala109Thr
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ala162Thr
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ala205Val
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ala85Val
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg113Gln
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg128Gln
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg13Gln
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg150Cys
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg150His
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg154Gln
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg15Pro
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg188Trp
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg191Gly
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg191Trp
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg78Trp
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg99Cys
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Asn178Ser
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Asp134Asn
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Asp23Asn
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Asp59His
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Glu118Lys
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Glu170Lys
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Glu181Lys
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Gly10Arg
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Gly141Ala
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Gly141Arg
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Gly211Arg
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Gly22Trp
Uncertain significance
Multiple submitters
Noonan syndrome
- RRAS p.Gly41Ser Uncertain significance Multiple submitters
-
RRAS p.Gly4Ala
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Gly4Trp
Uncertain significance
Multiple submitters
Noonan syndrome
- RRAS p.Gly91Arg Uncertain significance Multiple submitters
-
RRAS p.Lys208Arg
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Lys209Asn
Uncertain significance
Multiple submitters
Noonan syndrome
- RRAS p.Phe183Leu Uncertain significance Multiple submitters
-
RRAS p.Pro200Ser
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Pro202Leu
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Pro21Leu
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Pro21Ser
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ser158Phe
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ser163Pro
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ser204Gly
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ser43Arg
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ser56Cys
Uncertain significance
Multiple submitters
RRAS-related disorder
-
RRAS p.Thr124Arg
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Thr124Met
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Tyr53Phe
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Val107Met
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Val166Met
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Val216Ile
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Ala157Gly
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Ala159Pro
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Ala44Gly Uncertain significance Single submitter
- RRAS p.Ala44Val Uncertain significance Single submitter
- RRAS p.Ala5Gly Uncertain significance Single submitter
- RRAS p.Ala6Val Uncertain significance Single submitter
-
RRAS p.Ala85Thr
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Ala92Thr
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Ala92Val Uncertain significance Single submitter
-
RRAS p.Arg128Trp
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Arg150Pro
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Arg15Gln
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Arg15Gly
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Arg176Cys
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Arg188Gly
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Arg188Pro Uncertain significance Single submitter
-
RRAS p.Arg191Leu
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Arg207Lys Uncertain significance Single submitter
-
RRAS p.Arg78Gln
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Arg99His
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Arg99Ser
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Asn117Tyr Uncertain significance Single submitter
-
RRAS p.Asn178Thr
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Asp112Tyr Uncertain significance Single submitter
- RRAS p.Asp23Ala Uncertain significance Single submitter
-
RRAS p.Cys215Arg
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Gln149Arg Uncertain significance Single submitter
-
RRAS p.Gln185Lys
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Gln87Arg Uncertain significance Single submitter
- RRAS p.Gln87Glu Uncertain significance Single submitter
-
RRAS p.Glu118Gly
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Glu156Asp
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Glu170Gly
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Glu181Gln
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Glu28Asp
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Gly103Ser
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Gly10Ala
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Gly17Val
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Gly18Ala
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Gly18Glu
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Gly18Val Uncertain significance Single submitter
-
RRAS p.Gly22Arg
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Gly39Cys
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.His164Leu Uncertain significance Single submitter
-
RRAS p.His165Asp
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.His30Asp Uncertain significance Single submitter
- RRAS p.Ile110Leu Uncertain significance Single submitter
- RRAS p.Ile81Met Uncertain significance Single submitter
- RRAS p.Leu122Pro Uncertain significance Single submitter
- RRAS p.Leu146Arg Uncertain significance Single submitter
- RRAS p.Leu32Gln Uncertain significance Single submitter
-
RRAS p.Lys31Arg
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Lys42Glu
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Met98Val
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Phe135Leu
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Pro14His Uncertain significance Single submitter
- RRAS p.Pro14Leu Uncertain significance Single submitter
-
RRAS p.Pro153Thr
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Pro200Leu
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Pro206Ser Uncertain significance Single submitter
- RRAS p.Pro214Ser Uncertain significance Single submitter
-
RRAS p.Pro26Leu
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Pro76Leu
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Ser148Pro Uncertain significance Single submitter
- RRAS p.Ser155Pro Uncertain significance Single submitter
-
RRAS p.Ser172Leu
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Ser201Asn
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Ser27Cys Uncertain significance Single submitter
-
RRAS p.Ser3Arg
Uncertain significance
Single submitter
RRAS-related disorder
- RRAS p.Ser71Arg Uncertain significance Single submitter
-
RRAS p.Thr124Lys
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Thr29Ile Uncertain significance Single submitter
-
RRAS p.Thr61Asn
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Tyr168Cys
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Val119Gly
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Val152Ile
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Val152Leu
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Val179Met
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Val187Ala
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Val190Asp Uncertain significance Single submitter
-
RRAS p.Val33Ala
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Val55Met
Uncertain significance
Single submitter
Noonan syndrome
Predictors split 17
The independent predictors disagree with each other — read with care.
-
RRAS p.Arg132His
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg191Gln
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Cys70Tyr
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Phe49Leu
Benign/Likely benign
Multiple submitters
Noonan syndrome
-
RRAS p.Pro199Thr
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Pro25Leu
Likely benign
Multiple submitters
Noonan syndrome
-
RRAS p.Thr67Met
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Tyr97His
Uncertain significance
Multiple submitters
Noonan syndrome
-
RRAS p.Arg15Trp
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Glu28Lys Uncertain significance Single submitter
-
RRAS p.Gly17Trp
Conflicting
Single submitter
Noonan syndrome
- RRAS p.Gly74Ser Uncertain significance Single submitter
-
RRAS p.Phe123Ile
Uncertain significance
Single submitter
Noonan syndrome
-
RRAS p.Pro24Ser
Uncertain significance
Single submitter
Noonan syndrome
- RRAS p.Ser65Ala Uncertain significance Single submitter
- RRAS p.Val119Met Uncertain significance Single submitter
-
RRAS p.Val138Leu
Uncertain significance
Single submitter
Noonan syndrome
All RRAS variants
Conflicting classifications of pathogenicity 13
- c.344+6_344+7del Single submitter Noonan syndrome
- c.-5G>A Single submitter
- p.Ala205Thr Single submitter Noonan syndrome ⚠
- p.Ala77Thr Single submitter Noonan syndrome ⚠
- p.Arg188Gln Single submitter Noonan syndrome
- p.Gly161Ser Single submitter Noonan syndrome ⚠
- p.Gly17Trp Single submitter Noonan syndrome ⚠
- p.Gly39dup Single submitter Inborn genetic diseases
- p.Leu217Val Single submitter Noonan syndrome ⚠
- p.Ser158fs Single submitter Noonan syndrome
- p.Ser27= Single submitter RRAS-related disorder
- p.Val137Ile Single submitter Noonan syndrome ⚠
- p.Val190Leu Single submitter Noonan syndrome ⚠
Benign 8
- c.154-102T>G Multiple submitters
- c.241+54G>T Multiple submitters
- c.242-26G>A Multiple submitters
- c.454-10C>G Multiple submitters Noonan syndrome
- c.154-169C>T Single submitter
- c.154-262G>A Single submitter
- c.454-10del Single submitter Noonan syndrome
- c.454-10dup Single submitter Noonan syndrome
Benign/Likely benign 21
- c.154-4C>G Multiple submitters Noonan syndrome
- c.344+13G>A Multiple submitters Noonan syndrome
- c.344+17G>A Multiple submitters Noonan syndrome
- c.345-4G>A Multiple submitters Noonan syndrome
- c.453+20C>T Multiple submitters Noonan syndrome
- c.454-19G>C Multiple submitters Noonan syndrome
- c.454-4C>T Multiple submitters Noonan syndrome
- c.573-12G>A Multiple submitters Noonan syndrome
- c.*4A>G Multiple submitters
- p.Ala77= Multiple submitters Noonan syndrome
- p.Ala85= Multiple submitters Noonan syndrome
- p.Arg132= Multiple submitters Noonan syndrome
- p.Asn111= Multiple submitters Noonan syndrome
- p.Asn117= Multiple submitters Noonan syndrome
- p.Asp133Asn Multiple submitters Noonan syndrome
- p.Ile81= Multiple submitters Noonan syndrome
- p.Leu127= Multiple submitters Noonan syndrome
- p.Lys121Arg Multiple submitters Noonan syndrome
- p.Phe49Leu Multiple submitters Noonan syndrome ⚠
- p.Pro200= Multiple submitters Noonan syndrome
- p.Tyr58= Multiple submitters Noonan syndrome
Likely benign 123
- c.153+18G>A Multiple submitters Noonan syndrome
- c.154-5G>A Multiple submitters Noonan syndrome
- c.454-13C>T Multiple submitters Noonan syndrome
- c.454-19G>A Multiple submitters Noonan syndrome
- c.454-9T>A Multiple submitters Noonan syndrome
- c.454-9T>C Multiple submitters Noonan syndrome
- c.573-13C>T Multiple submitters Noonan syndrome
- c.573-19C>G Multiple submitters Noonan syndrome
- p.Ala189= Multiple submitters Noonan syndrome
- p.Arg15= Multiple submitters Noonan syndrome
- p.Asp133= Multiple submitters
- p.Asp180= Multiple submitters Noonan syndrome
- p.Asp23= Multiple submitters Noonan syndrome
- p.Cys215= Multiple submitters Noonan syndrome
- p.Glu181= Multiple submitters Noonan syndrome
- p.Glu195= Multiple submitters Noonan syndrome
- p.Gly17= Multiple submitters Noonan syndrome
- p.Gly210= Multiple submitters Noonan syndrome
- p.His102= Multiple submitters Noonan syndrome
- p.His165= Multiple submitters Noonan syndrome
- p.Leu218= Multiple submitters Noonan syndrome
- p.Leu32= Multiple submitters Noonan syndrome
- p.Lys121= Multiple submitters Noonan syndrome
- p.Lys208= Multiple submitters Noonan syndrome
- p.Phe108= Multiple submitters Noonan syndrome
- p.Phe160= Multiple submitters Noonan syndrome
- p.Phe54= Multiple submitters Noonan syndrome
- p.Phe90= Multiple submitters Noonan syndrome
- p.Pro214= Multiple submitters Noonan syndrome
- p.Pro25= Multiple submitters Noonan syndrome
- p.Pro25Leu Multiple submitters Noonan syndrome ⚠
- p.Ser155= Multiple submitters Noonan syndrome
- p.Ser172= Multiple submitters Noonan syndrome
- p.Thr67= Multiple submitters Noonan syndrome
- p.Thr84= Multiple submitters Noonan syndrome
- p.Tyr97= Multiple submitters Noonan syndrome
- p.Val140= Multiple submitters Noonan syndrome
- p.Val166= Multiple submitters Noonan syndrome
- p.Val33= Multiple submitters Noonan syndrome
- p.Val34= Multiple submitters Noonan syndrome
- c.153+10C>A Single submitter Noonan syndrome
- c.153+12_153+21del Single submitter
- c.153+12T>G Single submitter Noonan syndrome
- c.153+13del Single submitter
- c.153+17C>A Single submitter Noonan syndrome
- c.154-10A>T Single submitter Noonan syndrome
- c.154-171dup Single submitter
- c.154-6C>T Single submitter Noonan syndrome
- c.241+13A>G Single submitter Noonan syndrome
- c.241+17T>C Single submitter Noonan syndrome
- c.241+20A>G Single submitter Noonan syndrome
- c.241+9G>A Single submitter Noonan syndrome
- c.242-12_242-11del Single submitter Noonan syndrome
- c.242-17del Single submitter Noonan syndrome
- c.242-20C>T Single submitter Noonan syndrome
- c.242-4G>A Single submitter Noonan syndrome
- c.242-8C>G Single submitter Noonan syndrome
- c.242-8C>T Single submitter Noonan syndrome
- c.344+19G>C Single submitter Noonan syndrome
- c.345-11T>C Single submitter
- c.345-15C>T Single submitter Noonan syndrome
- c.345-19_345-18del Single submitter Noonan syndrome
- c.345-19C>G Single submitter Noonan syndrome
- c.345-5C>T Single submitter Noonan syndrome
- c.453+145A>G Single submitter
- c.453+16_453+17del Single submitter Noonan syndrome
- c.453+17T>C Single submitter Noonan syndrome
- c.453+18T>C Single submitter Noonan syndrome
- c.453+7G>A Single submitter Noonan syndrome
- c.454-10C>A Single submitter Noonan syndrome
- c.454-11C>G Single submitter Noonan syndrome
- c.454-11C>T Single submitter
- c.454-12C>T Single submitter Noonan syndrome
- c.454-20C>T Single submitter Noonan syndrome
- c.454-44_454-43del Single submitter
- c.454-6C>T Single submitter Noonan syndrome
- c.454-7C>T Single submitter Noonan syndrome
- c.572+10G>A Single submitter Noonan syndrome
- c.572+13C>A Single submitter Noonan syndrome
- c.572+20T>G Single submitter Noonan syndrome
- c.572+6C>T Single submitter
- c.573-12G>C Single submitter
- c.573-15G>A Single submitter Noonan syndrome
- c.573-15G>C Single submitter Noonan syndrome
- c.573-16del Single submitter Noonan syndrome
- c.573-16T>A Single submitter Noonan syndrome
- p.Arg11= Single submitter Noonan syndrome
- p.Asn178= Single submitter Noonan syndrome
- p.Asp131= Single submitter Noonan syndrome
- p.Gln125= Single submitter
- p.Gln196= Single submitter Noonan syndrome
- p.Gln96= Single submitter Noonan syndrome
- p.Glu147= Single submitter
- p.Gly10= Single submitter Noonan syndrome
- p.Gly10_Arg11= Single submitter
- p.Gly120= Single submitter Noonan syndrome
- p.Gly161= Single submitter
- p.Gly18= Single submitter
- p.Gly20= Single submitter
- p.Gly22= Single submitter Noonan syndrome
- p.Gly4= Single submitter
- p.Gly91= Single submitter
- p.His164= Single submitter Noonan syndrome
- p.Leu122= Single submitter
- p.Leu139= Single submitter
- p.Leu146= Single submitter Noonan syndrome
- p.Leu217= Single submitter Noonan syndrome
- p.Leu45= Single submitter
- p.Phe169= Single submitter
- p.Pro136= Single submitter Noonan syndrome
- p.Pro14= Single submitter Noonan syndrome
- p.Pro19= Single submitter
- p.Pro203= Single submitter Noonan syndrome
- p.Ser115= Single submitter
- p.Ser2= Single submitter
- p.Ser52= Single submitter
- p.Thr124= Single submitter
- p.Tyr193= Single submitter
- p.Tyr66= Single submitter Noonan syndrome
- p.Val137= Single submitter
- p.Val138= Single submitter
- p.Val72= Single submitter
- p.Arg13= No assertion criteria RRAS-related disorder
Uncertain significance 186
- p.Ala109Thr Multiple submitters Noonan syndrome ⚠
- p.Ala162Thr Multiple submitters Noonan syndrome ⚠
- p.Ala205Val Multiple submitters Noonan syndrome ⚠
- p.Ala5Thr Multiple submitters Noonan syndrome
- p.Ala85Val Multiple submitters Noonan syndrome ⚠
- p.Arg113Gln Multiple submitters Noonan syndrome ⚠
- p.Arg128Gln Multiple submitters Noonan syndrome ⚠
- p.Arg132Cys Multiple submitters Noonan syndrome
- p.Arg132His Multiple submitters Noonan syndrome ⚠
- p.Arg13Gln Multiple submitters Noonan syndrome ⚠
- p.Arg150Cys Multiple submitters Noonan syndrome ⚠
- p.Arg150His Multiple submitters Noonan syndrome ⚠
- p.Arg154Gln Multiple submitters Noonan syndrome ⚠
- p.Arg15Pro Multiple submitters Noonan syndrome ⚠
- p.Arg176His Multiple submitters Noonan syndrome
- p.Arg188Trp Multiple submitters Noonan syndrome ⚠
- p.Arg191Gln Multiple submitters Noonan syndrome ⚠
- p.Arg191Gly Multiple submitters Noonan syndrome ⚠
- p.Arg191Trp Multiple submitters Noonan syndrome ⚠
- p.Arg78Trp Multiple submitters Noonan syndrome ⚠
- p.Arg99Cys Multiple submitters Noonan syndrome ⚠
- p.Asn178Ser Multiple submitters Noonan syndrome ⚠
- p.Asp134Asn Multiple submitters Noonan syndrome ⚠
- p.Asp23Asn Multiple submitters Noonan syndrome ⚠
- p.Asp59His Multiple submitters Noonan syndrome ⚠
- p.Cys70Tyr Multiple submitters Noonan syndrome ⚠
- p.Glu118Lys Multiple submitters Noonan syndrome ⚠
- p.Glu170Lys Multiple submitters Noonan syndrome ⚠
- p.Glu181Lys Multiple submitters Noonan syndrome ⚠
- p.Gly10Arg Multiple submitters Noonan syndrome ⚠
- p.Gly141Ala Multiple submitters Noonan syndrome ⚠
- p.Gly141Arg Multiple submitters Noonan syndrome ⚠
- p.Gly211Arg Multiple submitters Noonan syndrome ⚠
- p.Gly22Trp Multiple submitters Noonan syndrome ⚠
- p.Gly41Ser Multiple submitters ⚠
- p.Gly4Ala Multiple submitters Noonan syndrome ⚠
- p.Gly4Trp Multiple submitters Noonan syndrome ⚠
- p.Gly91Arg Multiple submitters ⚠
- p.Lys208Arg Multiple submitters Noonan syndrome ⚠
- p.Lys209Asn Multiple submitters Noonan syndrome ⚠
- p.Phe183Leu Multiple submitters ⚠
- p.Pro199Thr Multiple submitters Noonan syndrome ⚠
- p.Pro200Ser Multiple submitters Noonan syndrome ⚠
- p.Pro202Leu Multiple submitters Noonan syndrome ⚠
- p.Pro21Leu Multiple submitters Noonan syndrome ⚠
- p.Pro21Ser Multiple submitters Noonan syndrome ⚠
- p.Ser158Phe Multiple submitters Noonan syndrome ⚠
- p.Ser163Pro Multiple submitters Noonan syndrome ⚠
- p.Ser204Gly Multiple submitters Noonan syndrome ⚠
- p.Ser43Arg Multiple submitters Noonan syndrome ⚠
- p.Ser56Cys Multiple submitters RRAS-related disorder ⚠
- p.Thr124Arg Multiple submitters Noonan syndrome ⚠
- p.Thr124Met Multiple submitters Noonan syndrome ⚠
- p.Thr67Met Multiple submitters Noonan syndrome ⚠
- p.Tyr53Phe Multiple submitters Noonan syndrome ⚠
- p.Tyr97His Multiple submitters Noonan syndrome ⚠
- p.Val107Met Multiple submitters Noonan syndrome ⚠
- p.Val166Met Multiple submitters Noonan syndrome ⚠
- p.Val216Ile Multiple submitters Noonan syndrome ⚠
- c.153+3A>G Single submitter Noonan syndrome
- c.241+5G>A Single submitter Noonan syndrome
- c.241+6G>A Single submitter Noonan syndrome
- c.241+6G>C Single submitter Noonan syndrome
- c.344+6del Single submitter
- c.345-14G>A Single submitter Noonan syndrome
- c.345-2A>C Single submitter
- c.453+4C>T Single submitter Noonan syndrome
- c.453+5G>A Single submitter Noonan syndrome
- c.453+6G>A Single submitter Noonan syndrome
- c.454-11_454-10delinsTG Single submitter Noonan syndrome
- c.572+3G>A Single submitter Noonan syndrome
- c.572+5G>A Single submitter Noonan syndrome
- c.573-4A>C Single submitter
- c.-27_-7dup Single submitter
- c.-9G>A Single submitter
- c.*230C>T Single submitter
- c.*5G>A Single submitter
- p.Ala157Gly Single submitter Noonan syndrome ⚠
- p.Ala159Pro Single submitter Noonan syndrome ⚠
- p.Ala182Gly Single submitter
- p.Ala44Gly Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Ala5Gly Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala85Thr Single submitter Noonan syndrome ⚠
- p.Ala92Thr Single submitter Noonan syndrome ⚠
- p.Ala92Val Single submitter ⚠
- p.Arg113Trp Single submitter Noonan syndrome
- p.Arg128Trp Single submitter Noonan syndrome ⚠
- p.Arg150Pro Single submitter Noonan syndrome ⚠
- p.Arg154Ter Single submitter Noonan syndrome
- p.Arg15Gln Single submitter Noonan syndrome ⚠
- p.Arg15Gly Single submitter Noonan syndrome ⚠
- p.Arg15Trp Single submitter Noonan syndrome ⚠
- p.Arg176Cys Single submitter Noonan syndrome ⚠
- p.Arg188Gly Single submitter Noonan syndrome ⚠
- p.Arg188Pro Single submitter ⚠
- p.Arg191Leu Single submitter Noonan syndrome ⚠
- p.Arg207Lys Single submitter ⚠
- p.Arg78Gln Single submitter Noonan syndrome ⚠
- p.Arg99His Single submitter Noonan syndrome ⚠
- p.Arg99Ser Single submitter Noonan syndrome ⚠
- p.Asn117Tyr Single submitter ⚠
- p.Asn142fs Single submitter
- p.Asn178Thr Single submitter Noonan syndrome ⚠
- p.Asp112Tyr Single submitter ⚠
- p.Asp23Ala Single submitter ⚠
- p.Cys215Arg Single submitter Noonan syndrome ⚠
- p.Gln149Arg Single submitter ⚠
- p.Gln149fs Single submitter
- p.Gln185Lys Single submitter Noonan syndrome ⚠
- p.Gln87Arg Single submitter ⚠
- p.Gln87Glu Single submitter ⚠
- p.Gln96Ter Single submitter Noonan syndrome
- p.Glu118Asp Single submitter Noonan syndrome
- p.Glu118Gly Single submitter Noonan syndrome ⚠
- p.Glu156Asp Single submitter Noonan syndrome ⚠
- p.Glu170Gly Single submitter Noonan syndrome ⚠
- p.Glu181Gln Single submitter Noonan syndrome ⚠
- p.Glu28Asp Single submitter Noonan syndrome ⚠
- p.Glu28Lys Single submitter ⚠
- p.Glu88fs Single submitter Noonan syndrome
- p.Glu89Ter Single submitter
- p.Gly103Ser Single submitter Noonan syndrome ⚠
- p.Gly10Ala Single submitter Noonan syndrome ⚠
- p.Gly17Val Single submitter Noonan syndrome ⚠
- p.Gly18Ala Single submitter Noonan syndrome ⚠
- p.Gly18Glu Single submitter Noonan syndrome ⚠
- p.Gly18Val Single submitter ⚠
- p.Gly22Arg Single submitter Noonan syndrome ⚠
- p.Gly39Cys Single submitter Noonan syndrome ⚠
- p.Gly74Ser Single submitter ⚠
- p.His164Leu Single submitter ⚠
- p.His165Asp Single submitter Noonan syndrome ⚠
- p.His30Asp Single submitter ⚠
- p.His30fs Single submitter Noonan syndrome
- p.Ile110Leu Single submitter ⚠
- p.Ile81Met Single submitter ⚠
- p.Leu122Pro Single submitter ⚠
- p.Leu146Arg Single submitter ⚠
- p.Leu146Met Single submitter Noonan syndrome
- p.Leu32Gln Single submitter ⚠
- p.Lys143Ter Single submitter Noonan syndrome
- p.Lys192= Single submitter Noonan syndrome
- p.Lys31Arg Single submitter Noonan syndrome ⚠
- p.Lys42Glu Single submitter Noonan syndrome ⚠
- p.Met1Arg Single submitter Noonan syndrome
- p.Met1Leu Single submitter Noonan syndrome
- p.Met1Lys Single submitter Noonan syndrome
- p.Met1Val Single submitter Noonan syndrome
- p.Met98Val Single submitter Noonan syndrome ⚠
- p.Phe123Ile Single submitter Noonan syndrome ⚠
- p.Phe135Leu Single submitter Noonan syndrome ⚠
- p.Pro14His Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Pro153Thr Single submitter Noonan syndrome ⚠
- p.Pro19fs Single submitter
- p.Pro200Leu Single submitter Noonan syndrome ⚠
- p.Pro206Ser Single submitter ⚠
- p.Pro214Ser Single submitter ⚠
- p.Pro24Ser Single submitter Noonan syndrome ⚠
- p.Pro26fs Single submitter Noonan syndrome
- p.Pro26Leu Single submitter Noonan syndrome ⚠
- p.Pro76Leu Single submitter Noonan syndrome ⚠
- p.Ser148Pro Single submitter ⚠
- p.Ser155Pro Single submitter ⚠
- p.Ser172Leu Single submitter Noonan syndrome ⚠
- p.Ser201Asn Single submitter Noonan syndrome ⚠
- p.Ser27Cys Single submitter ⚠
- p.Ser3Arg Single submitter RRAS-related disorder ⚠
- p.Ser65Ala Single submitter ⚠
- p.Ser71Arg Single submitter ⚠
- p.Thr124Lys Single submitter Noonan syndrome ⚠
- p.Thr29Ile Single submitter ⚠
- p.Thr61Asn Single submitter Noonan syndrome ⚠
- p.Tyr168Cys Single submitter Noonan syndrome ⚠
- p.Val119Gly Single submitter Noonan syndrome ⚠
- p.Val119Met Single submitter ⚠
- p.Val138Leu Single submitter Noonan syndrome ⚠
- p.Val152Ile Single submitter Noonan syndrome ⚠
- p.Val152Leu Single submitter Noonan syndrome ⚠
- p.Val179Met Single submitter Noonan syndrome ⚠
- p.Val187Ala Single submitter Noonan syndrome ⚠
- p.Val190Asp Single submitter ⚠
- p.Val33Ala Single submitter Noonan syndrome ⚠
- p.Val55Met Single submitter Noonan syndrome ⚠