RRS1 — 48 ClinVar variants
All ClinVar germline RRS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
2 Benign · 2 Likely benign · 44 Uncertain significance
Full RRS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RRS1 p.Ala164Thr Uncertain significance Single submitter
- RRS1 p.Ala196Val Uncertain significance Single submitter
- RRS1 p.Ala301Ser Uncertain significance Single submitter
- RRS1 p.Arg109Gln Uncertain significance Single submitter
- RRS1 p.Arg119His Uncertain significance Single submitter
- RRS1 p.Arg142Leu Uncertain significance Single submitter
- RRS1 p.Arg143Pro Uncertain significance Single submitter
- RRS1 p.Arg316Trp Uncertain significance Single submitter
- RRS1 p.Arg364Lys Uncertain significance Single submitter
- RRS1 p.Arg98His Uncertain significance Single submitter
- RRS1 p.Asn163Lys Uncertain significance Single submitter
- RRS1 p.Asn163Ser Uncertain significance Single submitter
- RRS1 p.Asn185Ser Uncertain significance Single submitter
- RRS1 p.Asn68Ser Uncertain significance Single submitter
- RRS1 p.Glu86Asp Uncertain significance Single submitter
- RRS1 p.Gly310Asp Uncertain significance Single submitter
- RRS1 p.Gly326Ser Uncertain significance Single submitter
- RRS1 p.Gly340Ser Uncertain significance Single submitter
- RRS1 p.Gly49Arg Uncertain significance Single submitter
- RRS1 p.Leu218Val Uncertain significance Single submitter
- RRS1 p.Lys128Thr Uncertain significance Single submitter
- RRS1 p.Lys173Arg Uncertain significance Single submitter
- RRS1 p.Lys178Arg Uncertain significance Single submitter
- RRS1 p.Lys302Glu Uncertain significance Single submitter
- RRS1 p.Thr210Ala Uncertain significance Single submitter
- RRS1 p.Val232Met Uncertain significance Single submitter
- RRS1 p.Val274Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- RRS1 p.Ala287Thr Uncertain significance Single submitter
- RRS1 p.Arg246Trp Uncertain significance Single submitter
- RRS1 p.Arg303Trp Uncertain significance Single submitter
- RRS1 p.Arg358Cys Uncertain significance Single submitter
- RRS1 p.Gln115Leu Uncertain significance Single submitter
- RRS1 p.Gly332Arg Uncertain significance Single submitter
- RRS1 p.Gly340Asp Uncertain significance Single submitter
- RRS1 p.Gly360Glu Uncertain significance Single submitter
- RRS1 p.Ile158Thr Uncertain significance Single submitter
- RRS1 p.Met275Ile Uncertain significance Single submitter
- RRS1 p.Pro104His Uncertain significance Single submitter
- RRS1 p.Pro104Ser Uncertain significance Single submitter
- RRS1 p.Pro108Leu Uncertain significance Single submitter
- RRS1 p.Ser344Tyr Uncertain significance Single submitter
All RRS1 variants
Benign 2
- p.Asp296Asn Multiple submitters
- p.Thr210= Multiple submitters
Likely benign 2
- p.Asn267Tyr Multiple submitters
- p.Cys52Arg Single submitter
Uncertain significance 44
- p.Ala164Thr Single submitter ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala287Thr Single submitter ⚠
- p.Ala301Ser Single submitter ⚠
- p.Arg109Gln Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg142Leu Single submitter ⚠
- p.Arg143His Single submitter
- p.Arg143Pro Single submitter ⚠
- p.Arg174Trp Single submitter
- p.Arg246Trp Single submitter ⚠
- p.Arg303Trp Single submitter ⚠
- p.Arg316Trp Single submitter ⚠
- p.Arg358Cys Single submitter ⚠
- p.Arg364Lys Single submitter ⚠
- p.Arg98His Single submitter ⚠
- p.Asn163Lys Single submitter ⚠
- p.Asn163Ser Single submitter ⚠
- p.Asn185Ser Single submitter ⚠
- p.Asn68Ser Single submitter ⚠
- p.Gln115Leu Single submitter ⚠
- p.Glu86Asp Single submitter ⚠
- p.Gly310Asp Single submitter ⚠
- p.Gly326Ser Single submitter ⚠
- p.Gly332Arg Single submitter ⚠
- p.Gly340Asp Single submitter ⚠
- p.Gly340Ser Single submitter ⚠
- p.Gly360Glu Single submitter ⚠
- p.Gly49Arg Single submitter ⚠
- p.Ile158Thr Single submitter ⚠
- p.Leu218Val Single submitter ⚠
- p.Lys128Thr Single submitter ⚠
- p.Lys173Arg Single submitter ⚠
- p.Lys178Arg Single submitter ⚠
- p.Lys302Glu Single submitter ⚠
- p.Met275Ile Single submitter ⚠
- p.Pro104His Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro240Leu Single submitter
- p.Ser344Tyr Single submitter ⚠
- p.Thr210Ala Single submitter ⚠
- p.Val232Met Single submitter ⚠
- p.Val274Ile Single submitter ⚠