RTF2 — 46 ClinVar variants
All ClinVar germline RTF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
46 Uncertain significance
Full RTF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RTF2 p.Ala270Thr Uncertain significance Single submitter
- RTF2 p.Arg147Pro Uncertain significance Single submitter
- RTF2 p.Arg46Gln Uncertain significance Single submitter
- RTF2 p.Asn87Ser Uncertain significance Single submitter
- RTF2 p.Asp212Tyr Uncertain significance Single submitter
- RTF2 p.Cys140Tyr Uncertain significance Single submitter
- RTF2 p.Glu72Gln Uncertain significance Single submitter
- RTF2 p.Glu72Lys Uncertain significance Single submitter
- RTF2 p.Gly130Asp Uncertain significance Single submitter
- RTF2 p.Gly130Val Uncertain significance Single submitter
- RTF2 p.Gly141Ser Uncertain significance Single submitter
- RTF2 p.His132Tyr Uncertain significance Single submitter
- RTF2 p.His297Tyr Uncertain significance Single submitter
- RTF2 p.Leu242Phe Uncertain significance Single submitter
- RTF2 p.Leu67Val Uncertain significance Single submitter
- RTF2 p.Lys103Arg Uncertain significance Single submitter
- RTF2 p.Lys110Arg Uncertain significance Single submitter
- RTF2 p.Lys239Asn Uncertain significance Single submitter
- RTF2 p.Lys69Thr Uncertain significance Single submitter
- RTF2 p.Met128Thr Uncertain significance Single submitter
- RTF2 p.Pro202Ala Uncertain significance Single submitter
- RTF2 p.Pro202Leu Uncertain significance Single submitter
- RTF2 p.Pro9Leu Uncertain significance Single submitter
- RTF2 p.Pro9Thr Uncertain significance Single submitter
- RTF2 p.Ser214Arg Uncertain significance Single submitter
- RTF2 p.Ser254Cys Uncertain significance Single submitter
- RTF2 p.Ser272Gly Uncertain significance Single submitter
- RTF2 p.Ser295Phe Uncertain significance Single submitter
- RTF2 p.Thr225Ile Uncertain significance Single submitter
- RTF2 p.Val123Ile Uncertain significance Single submitter
- RTF2 p.Val181Met Uncertain significance Single submitter
- RTF2 p.Val62Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- RTF2 p.Ala288Thr Uncertain significance Single submitter
- RTF2 p.Arg118Cys Uncertain significance Single submitter
- RTF2 p.Arg185Gly Uncertain significance Single submitter
- RTF2 p.Arg267Ser Uncertain significance Single submitter
- RTF2 p.Asn173Ser Uncertain significance Single submitter
- RTF2 p.Asp168Asn Uncertain significance Single submitter
- RTF2 p.Cys135Phe Uncertain significance Single submitter
- RTF2 p.Ile48Val Uncertain significance Single submitter
- RTF2 p.Lys23Glu Uncertain significance Single submitter
- RTF2 p.Tyr304Cys Uncertain significance Single submitter
All RTF2 variants
Uncertain significance 46
- p.Ala270Thr Single submitter ⚠
- p.Ala288Thr Single submitter ⚠
- p.Arg118Cys Single submitter ⚠
- p.Arg147Pro Single submitter ⚠
- p.Arg185Gly Single submitter ⚠
- p.Arg267Ser Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Asn173Ser Single submitter ⚠
- p.Asn87Ser Single submitter ⚠
- p.Asn96Ser Single submitter
- p.Asp168Asn Single submitter ⚠
- p.Asp178Gly Single submitter
- p.Asp212Tyr Single submitter ⚠
- p.Asp25Asn Single submitter
- p.Cys135Phe Single submitter ⚠
- p.Cys140Tyr Single submitter ⚠
- p.Glu72Gln Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Gly130Asp Single submitter ⚠
- p.Gly130Val Single submitter ⚠
- p.Gly141Ser Single submitter ⚠
- p.His132Tyr Single submitter ⚠
- p.His297Tyr Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Leu242Phe Single submitter ⚠
- p.Leu67Val Single submitter ⚠
- p.Lys103Arg Single submitter ⚠
- p.Lys110Arg Single submitter ⚠
- p.Lys239Asn Single submitter ⚠
- p.Lys23Glu Single submitter ⚠
- p.Lys69Glu Single submitter
- p.Lys69Thr Single submitter ⚠
- p.Met128Thr Single submitter ⚠
- p.Pro202Ala Single submitter ⚠
- p.Pro202Leu Single submitter ⚠
- p.Pro9Leu Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser214Arg Single submitter ⚠
- p.Ser254Cys Single submitter ⚠
- p.Ser272Gly Single submitter ⚠
- p.Ser295Phe Single submitter ⚠
- p.Thr225Ile Single submitter ⚠
- p.Tyr304Cys Single submitter ⚠
- p.Val123Ile Single submitter ⚠
- p.Val181Met Single submitter ⚠
- p.Val62Ile Single submitter ⚠