RTN3 — 158 ClinVar variants

All ClinVar germline RTN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →

3 Benign · 13 Likely benign · 142 Uncertain significance

Full RTN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 140

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 130

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All RTN3 variants

Benign 3

p.Ser10= Multiple submitters
p.Pro603Leu Single submitter
p.Val59= Single submitter

Likely benign 13

p.Arg764His Single submitter
p.Arg795His Single submitter
p.Asn337= Single submitter
p.Asp479Gly Single submitter
p.Gly535Asp Single submitter
p.Gly699Ser Single submitter
p.Ile1026= Single submitter
p.Lys172Glu Single submitter
p.Lys259Arg Single submitter
p.Pro722Leu Single submitter
p.Ser288Leu Single submitter
p.Thr290Ser Single submitter
p.Val140Ile Single submitter

Uncertain significance 142

p.Ala198Thr Single submitter ⚠
p.Ala256Thr Single submitter ⚠
p.Ala2Val Single submitter ⚠
p.Ala321Val Single submitter ⚠
p.Ala448Gly Single submitter ⚠
p.Ala510Pro Single submitter ⚠
p.Ala657Val Single submitter ⚠
p.Ala676Val Single submitter ⚠
p.Ala6Val Single submitter ⚠
p.Ala836Thr Single submitter ⚠
p.Ala871Ser Single submitter ⚠
p.Ala914Gly Single submitter ⚠
p.Arg155Cys Single submitter ⚠
p.Arg298Gly Single submitter ⚠
p.Arg304Cys Single submitter ⚠
p.Arg764Cys Single submitter ⚠
p.Arg795Cys Single submitter ⚠
p.Arg795Ser Single submitter ⚠
p.Arg851Ser Single submitter ⚠
p.Asn426Ile Single submitter ⚠
p.Asp258Ala Single submitter ⚠
p.Asp357Tyr Single submitter ⚠
p.Asp366Asn Single submitter ⚠
p.Asp502Gly Single submitter ⚠
p.Asp567Gly Single submitter ⚠
p.Asp587Tyr Single submitter ⚠
p.Asp594Asn Single submitter ⚠
p.Asp647Glu Single submitter ⚠
p.Asp737Val Single submitter ⚠
p.Asp802Val Single submitter ⚠
p.Asp846Asn Single submitter
p.Asp917Glu Single submitter ⚠
p.Asp919Asn Single submitter
p.Cys458Tyr Single submitter ⚠
p.Cys582Ser Single submitter ⚠
p.Gln111Glu Single submitter ⚠
p.Gln385His Single submitter ⚠
p.Gln484Pro Single submitter ⚠
p.Gln568Glu Single submitter ⚠
p.Gln713Leu Single submitter ⚠
p.Gln713Lys Single submitter ⚠
p.Gln729Glu Single submitter ⚠
p.Glu249Gly Single submitter ⚠
p.Glu282Lys Single submitter ⚠
p.Glu407Ala Single submitter ⚠
p.Glu449Val Single submitter ⚠
p.Glu579Ala Single submitter ⚠
p.Glu622Lys Single submitter ⚠
p.Glu691Asp Single submitter ⚠
p.Glu828Ala Single submitter ⚠
p.Gly1025Glu Single submitter ⚠
p.Gly222Ser Single submitter ⚠
p.Gly235Arg Single submitter ⚠
p.Gly303Ala Single submitter ⚠
p.Gly364Glu Single submitter ⚠
p.Gly665Arg Single submitter ⚠
p.Gly700Val Single submitter ⚠
p.His106Arg Single submitter ⚠
p.His121Asp Single submitter ⚠
p.His152Asp Single submitter ⚠
p.His333Arg Single submitter ⚠
p.His565Pro Single submitter ⚠
p.His639Tyr Single submitter ⚠
p.His694Arg Single submitter ⚠
p.His93Arg Single submitter ⚠
p.Ile158Val Single submitter ⚠
p.Ile359Phe Single submitter ⚠
p.Ile398Met Single submitter ⚠
p.Ile416Val Single submitter ⚠
p.Ile539Val Single submitter ⚠
p.Ile646Thr Single submitter ⚠
p.Ile646Val Single submitter ⚠
p.Ile805Phe Single submitter ⚠
p.Leu147Phe Single submitter ⚠
p.Leu322Pro Single submitter ⚠
p.Leu322Val Single submitter ⚠
p.Leu410Arg Single submitter ⚠
p.Leu72Val Single submitter ⚠
p.Leu751Ile Single submitter ⚠
p.Leu793Val Single submitter ⚠
p.Leu847Val Single submitter ⚠
p.Leu948Phe Single submitter ⚠
p.Leu958Phe Single submitter ⚠
p.Lys1030Asn Single submitter ⚠
p.Lys429Glu Single submitter ⚠
p.Lys434Asn Single submitter ⚠
p.Lys457Asn Single submitter ⚠
p.Lys469Glu Single submitter ⚠
p.Lys523Thr Single submitter ⚠
p.Lys641Glu Single submitter ⚠
p.Lys826Arg Single submitter ⚠
p.Lys855Thr Single submitter ⚠
p.Met127Lys Single submitter ⚠
p.Met130Thr Single submitter ⚠
p.Met307Ile Single submitter ⚠
p.Met307Val Single submitter ⚠
p.Met332Thr Single submitter ⚠
p.Met367Val Single submitter ⚠
p.Phe431Ser Single submitter ⚠
p.Phe431Tyr Single submitter ⚠
p.Phe625Val Single submitter ⚠
p.Phe912Ile Single submitter ⚠
p.Phe949Leu Single submitter ⚠
p.Pro112Ala Single submitter ⚠
p.Pro214Arg Single submitter ⚠
p.Ser229Pro Single submitter ⚠
p.Ser284Cys Single submitter ⚠
p.Ser308Pro Single submitter ⚠
p.Ser368Asn Single submitter ⚠
p.Ser382Gly Single submitter ⚠
p.Ser424Pro Single submitter ⚠
p.Ser460Pro Single submitter ⚠
p.Ser497Pro Single submitter ⚠
p.Ser708Arg Single submitter ⚠
p.Ser71Cys Single submitter ⚠
p.Ser869Pro Single submitter ⚠
p.Thr318Ala Single submitter ⚠
p.Thr336Ala Single submitter ⚠
p.Thr363Ala Single submitter ⚠
p.Thr383Ile Single submitter ⚠
p.Thr428Ala Single submitter ⚠
p.Thr512Ile Single submitter ⚠
p.Thr630Ala Single submitter ⚠
p.Thr661Ile Single submitter ⚠
p.Thr686Ile Single submitter ⚠
p.Thr779Ile Single submitter ⚠
p.Tyr217Asn Single submitter ⚠
p.Tyr226Phe Single submitter ⚠
p.Tyr994Cys Single submitter ⚠
p.Val151Asp Single submitter ⚠
p.Val376Gly Single submitter ⚠
p.Val421Leu Single submitter ⚠
p.Val465Met Single submitter ⚠
p.Val470Met Single submitter ⚠
p.Val471Phe Single submitter ⚠
p.Val559Ile Single submitter ⚠
p.Val559Phe Single submitter ⚠
p.Val598Phe Single submitter ⚠
p.Val615Leu Single submitter ⚠
p.Val629Leu Single submitter ⚠
p.Val629Met Single submitter ⚠
p.Val899Ile Single submitter ⚠