RTN4 — 219 ClinVar variants

All ClinVar germline RTN4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 195 flagged for review →

2 Conflicting · 6 Benign · 12 Likely benign · 199 Uncertain significance

Full RTN4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 195

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 182

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 182

Predictors split 11

The independent predictors disagree with each other — read with care.

All RTN4 variants

Conflicting classifications of pathogenicity 2

p.Asn941His Single submitter ⚠
p.Gln961Glu Single submitter ⚠

Benign 6

p.Glu899Gln Multiple submitters
p.Leu620= Multiple submitters
p.Pro992= Multiple submitters
p.Ser440Asn Multiple submitters
p.Ser920Cys Multiple submitters
p.Thr450Met Multiple submitters

Likely benign 12

p.Gly1070Ala Multiple submitters
p.Leu814Met Multiple submitters
p.Ala127= Single submitter
p.Ala685Val Single submitter
p.Ala76= Single submitter
p.Arg854= Single submitter
p.Ile924Val Single submitter
p.Leu687Val Single submitter
p.Met79Leu Single submitter
p.Thr945Ile Single submitter
p.Val374Ile Single submitter
p.Val542= Single submitter

Uncertain significance 199

p.Ala1046Ser Single submitter
p.Ala1082Asp Single submitter ⚠
p.Ala1082Gly Single submitter ⚠
p.Ala126Thr Single submitter ⚠
p.Ala141Gly Single submitter ⚠
p.Ala165Val Single submitter ⚠
p.Ala219Val Single submitter ⚠
p.Ala244Thr Single submitter ⚠
p.Ala280Thr Single submitter ⚠
p.Ala61Pro Single submitter ⚠
p.Ala629Ser Single submitter ⚠
p.Ala641Gly Single submitter ⚠
p.Ala66Ser Single submitter ⚠
p.Ala692Pro Single submitter ⚠
p.Ala994Gly Single submitter ⚠
p.Arg1107Ser Single submitter ⚠
p.Arg1157Gln Single submitter ⚠
p.Arg1189Cys Single submitter ⚠
p.Arg1189His Single submitter
p.Arg1189Ser Single submitter ⚠
p.Arg457Cys Single submitter ⚠
p.Arg457His Single submitter ⚠
p.Arg91Gln Single submitter ⚠
p.Asn1170Ser Single submitter ⚠
p.Asn370Asp Single submitter ⚠
p.Asn809Asp Single submitter ⚠
p.Asn83Lys Single submitter ⚠
p.Asp136Ala Single submitter ⚠
p.Asp208Val Single submitter ⚠
p.Asp286His Single submitter ⚠
p.Asp398Gly Single submitter ⚠
p.Asp44Glu Single submitter ⚠
p.Asp48Glu Single submitter ⚠
p.Asp751His Single submitter ⚠
p.Asp880Tyr Single submitter ⚠
p.Asp891Asn Single submitter ⚠
p.Asp905His Single submitter ⚠
p.Cys1101Tyr Single submitter ⚠
p.Gln154Arg Single submitter ⚠
p.Gln266Glu Single submitter ⚠
p.Gln266His Single submitter ⚠
p.Gln726Glu Single submitter ⚠
p.Gln760Glu Single submitter ⚠
p.Glu103Gln Single submitter ⚠
p.Glu1086Gln Single submitter
p.Glu248Asp Single submitter ⚠
p.Glu32Lys Single submitter ⚠
p.Glu38Lys Single submitter ⚠
p.Glu395Lys Single submitter ⚠
p.Glu39Lys Single submitter ⚠
p.Glu45Lys Single submitter ⚠
p.Glu494Gly Single submitter ⚠
p.Glu557Asp Single submitter ⚠
p.Glu560Gly Single submitter ⚠
p.Glu601Val Single submitter ⚠
p.Glu654Val Single submitter ⚠
p.Glu676Gly Single submitter ⚠
p.Glu762Lys Single submitter ⚠
p.Glu769Asp Single submitter ⚠
p.Glu781Ala Single submitter ⚠
p.Glu794Asp Single submitter ⚠
p.Glu870Lys Single submitter ⚠
p.Glu888Ala Single submitter ⚠
p.Glu965Lys Single submitter ⚠
p.Glu978Gly Single submitter ⚠
p.Glu986Gly Single submitter ⚠
p.Glu999Gln Single submitter ⚠
p.Gly1022Ala Single submitter ⚠
p.Gly1059Cys Single submitter ⚠
p.Gly253Arg Single submitter ⚠
p.Gly453Ser Single submitter ⚠
p.Gly628Asp Single submitter ⚠
p.Gly92Val Single submitter ⚠
p.Ile1043Phe Single submitter ⚠
p.Ile1083Val Single submitter ⚠
p.Ile1154Thr Single submitter ⚠
p.Ile1154Val Single submitter ⚠
p.Ile1162Leu Single submitter ⚠
p.Ile1180Val Single submitter ⚠
p.Ile285Thr Single submitter ⚠
p.Ile315Met Single submitter ⚠
p.Ile324Asn Single submitter ⚠
p.Ile677Met Single submitter ⚠
p.Ile683Met Single submitter ⚠
p.Ile695Val Single submitter ⚠
p.Ile865Val Single submitter ⚠
p.Ile924Arg Single submitter ⚠
p.Ile964Arg Single submitter ⚠
p.Leu1077Val Single submitter
p.Leu1087Phe Single submitter ⚠
p.Leu1096Phe Single submitter
p.Leu1140Pro Single submitter ⚠
p.Leu1145Phe Single submitter ⚠
p.Leu416Trp Single submitter ⚠
p.Leu590Pro Single submitter ⚠
p.Leu63Val Single submitter ⚠
p.Leu892Ile Single submitter ⚠
p.Leu981Phe Single submitter ⚠
p.Leu9Pro Single submitter ⚠
p.Lys1058Glu Single submitter ⚠
p.Lys132Asn Single submitter ⚠
p.Lys210Arg Single submitter ⚠
p.Lys326Glu Single submitter ⚠
p.Lys423Ile Single submitter ⚠
p.Lys513Glu Single submitter ⚠
p.Lys706Glu Single submitter ⚠
p.Lys785Thr Single submitter ⚠
p.Lys897Glu Single submitter ⚠
p.Met1177Thr Single submitter ⚠
p.Met1177Val Single submitter ⚠
p.Met207Thr Single submitter ⚠
p.Met300Ile Single submitter ⚠
p.Met380Val Single submitter ⚠
p.Met405Ile Single submitter ⚠
p.Met586Lys Single submitter ⚠
p.Met616Thr Single submitter ⚠
p.Met79Thr Single submitter ⚠
p.Phe369Cys Single submitter ⚠
p.Phe387Ile Single submitter ⚠
p.Phe390Leu Single submitter ⚠
p.Phe425Ser Single submitter ⚠
p.Phe85Leu Single submitter ⚠
p.Phe85Tyr Single submitter ⚠
p.Pro110Arg Single submitter ⚠
p.Pro112Leu Single submitter ⚠
p.Pro139Leu Single submitter ⚠
p.Pro140Leu Single submitter ⚠
p.Pro146Arg Single submitter ⚠
p.Pro146Leu Single submitter ⚠
p.Pro147Ser Single submitter ⚠
p.Pro148Arg Single submitter ⚠
p.Pro161Leu Single submitter ⚠
p.Pro162Arg Single submitter ⚠
p.Pro162Thr Single submitter ⚠
p.Pro164Gln Single submitter ⚠
p.Pro176His Single submitter ⚠
p.Pro19Ser Single submitter ⚠
p.Pro308Ala Single submitter ⚠
p.Pro319Thr Single submitter ⚠
p.Pro517Thr Single submitter ⚠
p.Pro609Leu Single submitter
p.Pro67Ala Single submitter ⚠
p.Pro713Leu Single submitter ⚠
p.Pro72Ser Single submitter ⚠
p.Pro793Thr Single submitter ⚠
p.Pro87Leu Single submitter ⚠
p.Pro8Ser Single submitter ⚠
p.Pro904Leu Single submitter ⚠
p.Pro90Ser Single submitter ⚠
p.Pro970Ser Single submitter ⚠
p.Pro98Leu Single submitter ⚠
p.Ser1094Cys Single submitter ⚠
p.Ser111Arg Single submitter ⚠
p.Ser11Ala Single submitter ⚠
p.Ser131Phe Single submitter ⚠
p.Ser181Phe Single submitter ⚠
p.Ser203Cys Single submitter ⚠
p.Ser203Phe Single submitter ⚠
p.Ser307Pro Single submitter ⚠
p.Ser361Pro Single submitter ⚠
p.Ser449Asn Single submitter ⚠
p.Ser636Pro Single submitter ⚠
p.Ser637Pro Single submitter ⚠
p.Ser696Pro Single submitter ⚠
p.Ser739Leu Single submitter ⚠
p.Ser789Thr Single submitter ⚠
p.Ser7Cys Single submitter ⚠
p.Ser806Arg Single submitter ⚠
p.Ser862Thr Single submitter ⚠
p.Ser877Cys Single submitter ⚠
p.Ser909Leu Single submitter ⚠
p.Ser933Ile Single submitter ⚠
p.Ser935Leu Single submitter ⚠
p.Ser956Phe Single submitter ⚠
p.Thr1102Met Single submitter ⚠
p.Thr1139Pro Single submitter ⚠
p.Thr216Ala Single submitter ⚠
p.Thr445Asn Single submitter ⚠
p.Thr477Ala Single submitter ⚠
p.Thr506Ile Single submitter ⚠
p.Thr569Arg Single submitter ⚠
p.Thr810Ala Single submitter ⚠
p.Thr813Ala Single submitter ⚠
p.Thr873Ile Single submitter ⚠
p.Tyr1042Cys Single submitter ⚠
p.Tyr1130Cys Single submitter ⚠
p.Tyr461Cys Single submitter ⚠
p.Tyr591Asn Single submitter ⚠
p.Tyr694Cys Single submitter ⚠
p.Tyr799Cys Single submitter ⚠
p.Val1020Met Single submitter ⚠
p.Val1116Ile Single submitter ⚠
p.Val113Ala Single submitter ⚠
p.Val128Phe Single submitter ⚠
p.Val359Ala Single submitter ⚠
p.Val393Leu Single submitter ⚠
p.Val543Met Single submitter ⚠
p.Val644Ile Single submitter ⚠
p.Val756Ile Single submitter ⚠