RXFP3 — 75 ClinVar variants
All ClinVar germline RXFP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
1 Benign · 4 Likely benign · 70 Uncertain significance
Full RXFP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RXFP3 p.Ala143Ser Uncertain significance Single submitter
- RXFP3 p.Ala15Gly Uncertain significance Single submitter
- RXFP3 p.Ala175Gly Uncertain significance Single submitter
- RXFP3 p.Ala185Thr Uncertain significance Single submitter
- RXFP3 p.Ala223Gly Uncertain significance Single submitter
- RXFP3 p.Ala226Ser Uncertain significance Single submitter
- RXFP3 p.Ala299Gly Uncertain significance Single submitter
- RXFP3 p.Ala316Val Uncertain significance Single submitter
- RXFP3 p.Ala408Glu Uncertain significance Single submitter
- RXFP3 p.Ala408Val Uncertain significance Single submitter
- RXFP3 p.Ala433Ser Uncertain significance Single submitter
- RXFP3 p.Ala74Ser Uncertain significance Single submitter
- RXFP3 p.Ala93Thr Uncertain significance Single submitter
- RXFP3 p.Arg312Ser Uncertain significance Single submitter
- RXFP3 p.Arg406Gly Uncertain significance Single submitter
- RXFP3 p.Arg406Leu Uncertain significance Single submitter
- RXFP3 p.Asp296Glu Uncertain significance Single submitter
- RXFP3 p.Gln429His Uncertain significance Single submitter
- RXFP3 p.Gln432His Uncertain significance Single submitter
- RXFP3 p.Gln44Arg Uncertain significance Single submitter
- RXFP3 p.Gly111Val Uncertain significance Single submitter
- RXFP3 p.Gly305Glu Uncertain significance Single submitter
- RXFP3 p.Gly39Ser Uncertain significance Single submitter
- RXFP3 p.Gly430Trp Uncertain significance Single submitter
- RXFP3 p.Gly458Glu Uncertain significance Single submitter
- RXFP3 p.Gly69Val Uncertain significance Single submitter
- RXFP3 p.His196Arg Uncertain significance Single submitter
- RXFP3 p.Ile117Val Uncertain significance Single submitter
- RXFP3 p.Ile284Val Uncertain significance Single submitter
- RXFP3 p.Ile330Thr Uncertain significance Single submitter
- RXFP3 p.Leu101Val Uncertain significance Single submitter
- RXFP3 p.Leu105Pro Uncertain significance Single submitter
- RXFP3 p.Leu206Arg Uncertain significance Single submitter
- RXFP3 p.Leu206Pro Uncertain significance Single submitter
- RXFP3 p.Leu32Pro Uncertain significance Single submitter
- RXFP3 p.Leu337Met Uncertain significance Single submitter
- RXFP3 p.Leu345Val Uncertain significance Single submitter
- RXFP3 p.Leu391Pro Uncertain significance Single submitter
- RXFP3 p.Lys107Asn Uncertain significance Single submitter
- RXFP3 p.Lys20Gln Uncertain significance Single submitter
- RXFP3 p.Lys353Arg Uncertain significance Single submitter
- RXFP3 p.Met109Arg Uncertain significance Single submitter
- RXFP3 p.Met154Thr Uncertain significance Single submitter
- RXFP3 p.Met160Val Uncertain significance Single submitter
- RXFP3 p.Phe137Ser Uncertain significance Single submitter
- RXFP3 p.Pro136Thr Uncertain significance Single submitter
- RXFP3 p.Pro279Leu Uncertain significance Single submitter
- RXFP3 p.Pro434Arg Uncertain significance Single submitter
- RXFP3 p.Pro436Ala Uncertain significance Single submitter
- RXFP3 p.Pro437Thr Uncertain significance Single submitter
- RXFP3 p.Pro443Arg Uncertain significance Single submitter
- RXFP3 p.Pro57Arg Uncertain significance Single submitter
- RXFP3 p.Pro65Ser Uncertain significance Single submitter
- RXFP3 p.Pro66Leu Uncertain significance Single submitter
- RXFP3 p.Ser116Pro Uncertain significance Single submitter
- RXFP3 p.Ser382Asn Uncertain significance Single submitter
- RXFP3 p.Ser414Gly Uncertain significance Single submitter
- RXFP3 p.Ser467Phe Uncertain significance Single submitter
- RXFP3 p.Thr193Ala Uncertain significance Single submitter
- RXFP3 p.Val249Leu Uncertain significance Single submitter
- RXFP3 p.Val392Leu Uncertain significance Single submitter
- RXFP3 p.Val452Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All RXFP3 variants
Benign 1
- p.Leu124= Multiple submitters
Likely benign 4
- p.Ala175Ser Single submitter
- p.Met3Val Single submitter
- p.Ser269Leu Single submitter
- p.Val332Asp No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 70
- p.Ala143Ser Single submitter ⚠
- p.Ala15Gly Single submitter ⚠
- p.Ala175Gly Single submitter ⚠
- p.Ala185Thr Single submitter ⚠
- p.Ala187Asp Single submitter
- p.Ala223Gly Single submitter ⚠
- p.Ala226Ser Single submitter ⚠
- p.Ala299Gly Single submitter ⚠
- p.Ala316Val Single submitter ⚠
- p.Ala408Glu Single submitter ⚠
- p.Ala408Val Single submitter ⚠
- p.Ala433Ser Single submitter ⚠
- p.Ala74Ser Single submitter ⚠
- p.Ala93Thr Single submitter ⚠
- p.Arg312Ser Single submitter ⚠
- p.Arg397Gly Single submitter
- p.Arg406Gly Single submitter ⚠
- p.Arg406Leu Single submitter ⚠
- p.Asn342Lys Single submitter ⚠
- p.Asp296Glu Single submitter ⚠
- p.Gln429His Single submitter ⚠
- p.Gln432His Single submitter ⚠
- p.Gln44Arg Single submitter ⚠
- p.Gly111Val Single submitter ⚠
- p.Gly305Glu Single submitter ⚠
- p.Gly39Ser Single submitter ⚠
- p.Gly430Trp Single submitter ⚠
- p.Gly458Glu Single submitter ⚠
- p.Gly69Val Single submitter ⚠
- p.His196Arg Single submitter ⚠
- p.Ile117Val Single submitter ⚠
- p.Ile284Val Single submitter ⚠
- p.Ile330Thr Single submitter ⚠
- p.Leu101Val Single submitter ⚠
- p.Leu105Pro Single submitter ⚠
- p.Leu126Gln Single submitter
- p.Leu206Arg Single submitter ⚠
- p.Leu206Pro Single submitter ⚠
- p.Leu32Pro Single submitter ⚠
- p.Leu337Met Single submitter ⚠
- p.Leu345Val Single submitter ⚠
- p.Leu391Pro Single submitter ⚠
- p.Lys107Asn Single submitter ⚠
- p.Lys20Gln Single submitter ⚠
- p.Lys353Arg Single submitter ⚠
- p.Met109Arg Single submitter ⚠
- p.Met154Thr Single submitter ⚠
- p.Met160Val Single submitter ⚠
- p.Phe137Ser Single submitter ⚠
- p.Pro136Thr Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro434Arg Single submitter ⚠
- p.Pro436Ala Single submitter ⚠
- p.Pro437Thr Single submitter ⚠
- p.Pro443Arg Single submitter ⚠
- p.Pro57Arg Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Pro66Leu Single submitter ⚠
- p.Ser116Pro Single submitter ⚠
- p.Ser229Leu Single submitter
- p.Ser374Gly Single submitter ⚠
- p.Ser382Asn Single submitter ⚠
- p.Ser414Gly Single submitter ⚠
- p.Ser467Phe Single submitter ⚠
- p.Thr193Ala Single submitter ⚠
- p.Thr238Met Single submitter ⚠
- p.Tyr287Cys Single submitter ⚠
- p.Val249Leu Single submitter ⚠
- p.Val392Leu Single submitter ⚠
- p.Val452Ile Single submitter ⚠