RXFP4 — 75 ClinVar variants
All ClinVar germline RXFP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
5 Likely benign · 70 Uncertain significance
Full RXFP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RXFP4 p.Arg328Trp Uncertain significance Multiple submitters
- RXFP4 p.Ala147Val Uncertain significance Single submitter
- RXFP4 p.Ala170Thr Uncertain significance Single submitter
- RXFP4 p.Ala203Val Uncertain significance Single submitter
- RXFP4 p.Ala343Ser Uncertain significance Single submitter
- RXFP4 p.Ala68Val Uncertain significance Single submitter
- RXFP4 p.Ala99Val Uncertain significance Single submitter
- RXFP4 p.Arg159Gln Uncertain significance Single submitter
- RXFP4 p.Arg194Cys Uncertain significance Single submitter
- RXFP4 p.Arg194His Uncertain significance Single submitter
- RXFP4 p.Arg234Gln Uncertain significance Single submitter
- RXFP4 p.Arg236Gln Uncertain significance Single submitter
- RXFP4 p.Arg236Trp Uncertain significance Single submitter
- RXFP4 p.Arg237Gln Uncertain significance Single submitter
- RXFP4 p.Arg237Trp Uncertain significance Single submitter
- RXFP4 p.Arg246Cys Uncertain significance Single submitter
- RXFP4 p.Arg246His Uncertain significance Single submitter
- RXFP4 p.Arg249Cys Uncertain significance Single submitter
- RXFP4 p.Arg313Lys Uncertain significance Single submitter
- RXFP4 p.Arg317Leu Uncertain significance Single submitter
- RXFP4 p.Arg328Gln Uncertain significance Single submitter
- RXFP4 p.Arg350Gln Uncertain significance Single submitter
- RXFP4 p.Arg360Cys Uncertain significance Single submitter
- RXFP4 p.Arg69Gln Uncertain significance Single submitter
- RXFP4 p.Arg69Trp Uncertain significance Single submitter
- RXFP4 p.Asn66Tyr Uncertain significance Single submitter
- RXFP4 p.Asp275Gly Uncertain significance Single submitter
- RXFP4 p.Asp28Asn Uncertain significance Single submitter
- RXFP4 p.Cys258Tyr Uncertain significance Single submitter
- RXFP4 p.Gly20Arg Uncertain significance Single submitter
- RXFP4 p.Gly322Cys Uncertain significance Single submitter
- RXFP4 p.Gly371Arg Uncertain significance Single submitter
- RXFP4 p.Gly374Arg Uncertain significance Single submitter
- RXFP4 p.His152Gln Uncertain significance Single submitter
- RXFP4 p.Ile160Arg Uncertain significance Single submitter
- RXFP4 p.Met145Val Uncertain significance Single submitter
- RXFP4 p.Phe14Val Uncertain significance Single submitter
- RXFP4 p.Phe274Ser Uncertain significance Single submitter
- RXFP4 p.Pro10Ser Uncertain significance Single submitter
- RXFP4 p.Pro2Leu Uncertain significance Single submitter
- RXFP4 p.Pro373Thr Uncertain significance Single submitter
- RXFP4 p.Ser101Leu Uncertain significance Single submitter
- RXFP4 p.Ser154Ala Uncertain significance Single submitter
- RXFP4 p.Ser19Ala Uncertain significance Single submitter
- RXFP4 p.Ser22Gly Uncertain significance Single submitter
- RXFP4 p.Thr363Ile Uncertain significance Single submitter
- RXFP4 p.Tyr224His Uncertain significance Single submitter
- RXFP4 p.Tyr284Ser Uncertain significance Single submitter
- RXFP4 p.Val185Met Uncertain significance Single submitter
- RXFP4 p.Val243Gly Uncertain significance Single submitter
- RXFP4 p.Val244Met Uncertain significance Single submitter
- RXFP4 p.Val265Phe Uncertain significance Single submitter
- RXFP4 p.Val272Leu Uncertain significance Single submitter
- RXFP4 p.Val342Ala Uncertain significance Single submitter
- RXFP4 p.Val42Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- RXFP4 p.Ala158Asp Uncertain significance Single submitter
- RXFP4 p.Ala164Glu Uncertain significance Single submitter
- RXFP4 p.Arg139His Uncertain significance Single submitter
- RXFP4 p.Arg189Cys Uncertain significance Single submitter
- RXFP4 p.Arg233Trp Uncertain significance Single submitter
- RXFP4 p.Arg314Trp Uncertain significance Single submitter
- RXFP4 p.Arg317Trp Uncertain significance Single submitter
- RXFP4 p.Leu327Pro Uncertain significance Single submitter
- RXFP4 p.Pro75Ser Uncertain significance Single submitter
- RXFP4 p.Ser300Asn Uncertain significance Single submitter
All RXFP4 variants
Likely benign 5
- p.Arg233Gln Single submitter
- p.Arg314Gln Single submitter
- p.Gly336Arg Single submitter
- p.Ile160Val Single submitter
- p.Val219Ile Single submitter
Uncertain significance 70
- p.Arg328Trp Multiple submitters ⚠
- p.Ala147Val Single submitter ⚠
- p.Ala158Asp Single submitter ⚠
- p.Ala164Glu Single submitter ⚠
- p.Ala170Thr Single submitter ⚠
- p.Ala203Val Single submitter ⚠
- p.Ala343Ser Single submitter ⚠
- p.Ala68Val Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg189Cys Single submitter ⚠
- p.Arg194Cys Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg233Trp Single submitter ⚠
- p.Arg234Gln Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg236Trp Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg237Trp Single submitter ⚠
- p.Arg246Cys Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg313Lys Single submitter ⚠
- p.Arg314Trp Single submitter ⚠
- p.Arg317Leu Single submitter ⚠
- p.Arg317Trp Single submitter ⚠
- p.Arg328Gln Single submitter ⚠
- p.Arg350Gln Single submitter ⚠
- p.Arg360Cys Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg69Trp Single submitter ⚠
- p.Asn66Tyr Single submitter ⚠
- p.Asp275Gly Single submitter ⚠
- p.Asp28Asn Single submitter ⚠
- p.Cys258Ser Single submitter
- p.Cys258Tyr Single submitter ⚠
- p.Gly20Arg Single submitter ⚠
- p.Gly322Cys Single submitter ⚠
- p.Gly371Arg Single submitter ⚠
- p.Gly374Arg Single submitter ⚠
- p.His152Gln Single submitter ⚠
- p.His263Asp Single submitter
- p.Ile160Arg Single submitter ⚠
- p.Leu327Pro Single submitter ⚠
- p.Lys115Glu Single submitter
- p.Met145Val Single submitter ⚠
- p.Phe14Val Single submitter ⚠
- p.Phe274Ser Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro2Leu Single submitter ⚠
- p.Pro373Thr Single submitter ⚠
- p.Pro75Ser Single submitter ⚠
- p.Ser101Leu Single submitter ⚠
- p.Ser154Ala Single submitter ⚠
- p.Ser19Ala Single submitter ⚠
- p.Ser22Gly Single submitter ⚠
- p.Ser300Asn Single submitter ⚠
- p.Thr294Ile Single submitter
- p.Thr363Ile Single submitter ⚠
- p.Trp279Cys Single submitter
- p.Tyr224His Single submitter ⚠
- p.Tyr284Ser Single submitter ⚠
- p.Val185Met Single submitter ⚠
- p.Val243Gly Single submitter ⚠
- p.Val244Met Single submitter ⚠
- p.Val265Phe Single submitter ⚠
- p.Val272Leu Single submitter ⚠
- p.Val342Ala Single submitter ⚠
- p.Val42Leu Single submitter ⚠