RXRA — 28 ClinVar variants
All ClinVar germline RXRA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Likely pathogenic · 2 Likely benign · 25 Uncertain significance
Full RXRA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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RXRA p.Ser224Asn
Likely pathogenic
No assertion criteria
plasma cell myeloma
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RXRA p.Ala457Thr Uncertain significance Single submitter
- RXRA p.Arg191Cys Uncertain significance Single submitter
- RXRA p.Arg211Cys Uncertain significance Single submitter
- RXRA p.Asn114Ser Uncertain significance Single submitter
- RXRA p.Asn216Lys Uncertain significance Single submitter
- RXRA p.Gln411His Uncertain significance Single submitter
- RXRA p.Glu105Lys Uncertain significance Single submitter
- RXRA p.Gly255Ala Uncertain significance Single submitter
- RXRA p.Gly90Cys Uncertain significance Single submitter
- RXRA p.Ile318Val Uncertain significance Single submitter
- RXRA p.Met454Ile Uncertain significance Single submitter
- RXRA p.Met72Arg Uncertain significance Single submitter
- RXRA p.Pro35Leu Uncertain significance Single submitter
- RXRA p.Ser225Asn Uncertain significance Single submitter
- RXRA p.Ser259Asn Uncertain significance Single submitter
- RXRA p.Ser32Leu Uncertain significance Single submitter
- RXRA p.Val116Ile Uncertain significance Single submitter
- RXRA p.Val119Ile Uncertain significance Single submitter
- RXRA p.Val250Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All RXRA variants
Likely pathogenic 1
- p.Ser224Asn No assertion criteria plasma cell myeloma ⚠
Uncertain significance 25
- c.28+1G>A Single submitter
- p.Ala391Val Single submitter ⚠
- p.Ala457Thr Single submitter ⚠
- p.Ala457Val Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg211Cys Single submitter ⚠
- p.Asn114Ser Single submitter ⚠
- p.Asn216Lys Single submitter ⚠
- p.Gln411His Single submitter ⚠
- p.Glu105Lys Single submitter ⚠
- p.Glu221Gln Single submitter ⚠
- p.Gly255Ala Single submitter ⚠
- p.Gly90Cys Single submitter ⚠
- p.His459Tyr Single submitter ⚠
- p.Ile318Val Single submitter ⚠
- p.Met198Thr Single submitter ⚠
- p.Met454Ile Single submitter ⚠
- p.Met72Arg Single submitter ⚠
- p.Pro35Leu Single submitter ⚠
- p.Ser225Asn Single submitter ⚠
- p.Ser259Asn Single submitter ⚠
- p.Ser32Leu Single submitter ⚠
- p.Val116Ile Single submitter ⚠
- p.Val119Ile Single submitter ⚠
- p.Val250Met Single submitter ⚠