RXRG — 41 ClinVar variants
All ClinVar germline RXRG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Likely benign · 40 Uncertain significance
Full RXRG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- RXRG p.Ala272Thr Uncertain significance Single submitter
- RXRG p.Ala31Thr Uncertain significance Single submitter
- RXRG p.Ala52Val Uncertain significance Single submitter
- RXRG p.Arg422Cys Uncertain significance Single submitter
- RXRG p.Arg71Gln Uncertain significance Single submitter
- RXRG p.Arg71Gly Uncertain significance Single submitter
- RXRG p.Arg71Leu Uncertain significance Single submitter
- RXRG p.Asn104Lys Uncertain significance Single submitter
- RXRG p.Asp255His Uncertain significance Single submitter
- RXRG p.Asp40Asn Uncertain significance Single submitter
- RXRG p.Gln197Glu Uncertain significance Single submitter
- RXRG p.Gln362Arg Uncertain significance Single submitter
- RXRG p.Glu395Gly Uncertain significance Single submitter
- RXRG p.Gly120Arg Uncertain significance Single submitter
- RXRG p.Gly20Val Uncertain significance Single submitter
- RXRG p.Ile90Val Uncertain significance Single submitter
- RXRG p.Leu33Phe Uncertain significance Single submitter
- RXRG p.Leu434Val Uncertain significance Single submitter
- RXRG p.Met234Ile Uncertain significance Single submitter
- RXRG p.Met453Thr Uncertain significance Single submitter
- RXRG p.Pro116Thr Uncertain significance Single submitter
- RXRG p.Pro119Thr Uncertain significance Single submitter
- RXRG p.Pro379Thr Uncertain significance Single submitter
- RXRG p.Pro410Gln Uncertain significance Single submitter
- RXRG p.Ser291Phe Uncertain significance Single submitter
- RXRG p.Ser34Ala Uncertain significance Single submitter
- RXRG p.Ser57Asn Uncertain significance Single submitter
- RXRG p.Thr48Ile Uncertain significance Single submitter
- RXRG p.Thr61Asn Uncertain significance Single submitter
- RXRG p.Tyr193His Uncertain significance Single submitter
- RXRG p.Val106Ala Uncertain significance Single submitter
- RXRG p.Val135Phe Uncertain significance Single submitter
- RXRG p.Val281Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- RXRG p.Arg217Gln Uncertain significance Single submitter
- RXRG p.Arg219Gly Uncertain significance Single submitter
- RXRG p.Arg286His Uncertain significance Single submitter
- RXRG p.Gly132Arg Uncertain significance Single submitter
- RXRG p.Ile138Phe Uncertain significance Single submitter
- RXRG p.Val246Ile Uncertain significance Single submitter
All RXRG variants
Likely benign 1
- p.Thr228Ser Single submitter
Uncertain significance 40
- p.Ala272Thr Single submitter ⚠
- p.Ala31Thr Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg219Gly Single submitter ⚠
- p.Arg286His Single submitter ⚠
- p.Arg422Cys Single submitter ⚠
- p.Arg71Gln Single submitter ⚠
- p.Arg71Gly Single submitter ⚠
- p.Arg71Leu Single submitter ⚠
- p.Asn104Lys Single submitter ⚠
- p.Asp255His Single submitter ⚠
- p.Asp40Asn Single submitter ⚠
- p.Gln197Glu Single submitter ⚠
- p.Gln362Arg Single submitter ⚠
- p.Glu395Gly Single submitter ⚠
- p.Gly117Arg Single submitter
- p.Gly120Arg Single submitter ⚠
- p.Gly132Arg Single submitter ⚠
- p.Gly20Val Single submitter ⚠
- p.Ile138Phe Single submitter ⚠
- p.Ile90Val Single submitter ⚠
- p.Leu33Phe Single submitter ⚠
- p.Leu434Val Single submitter ⚠
- p.Met234Ile Single submitter ⚠
- p.Met453Thr Single submitter ⚠
- p.Pro116Thr Single submitter ⚠
- p.Pro119Thr Single submitter ⚠
- p.Pro379Thr Single submitter ⚠
- p.Pro410Gln Single submitter ⚠
- p.Ser291Phe Single submitter ⚠
- p.Ser34Ala Single submitter ⚠
- p.Ser57Asn Single submitter ⚠
- p.Thr48Ile Single submitter ⚠
- p.Thr61Asn Single submitter ⚠
- p.Tyr193His Single submitter ⚠
- p.Val106Ala Single submitter ⚠
- p.Val135Phe Single submitter ⚠
- p.Val246Ile Single submitter ⚠
- p.Val281Ile Single submitter ⚠