S100A11 — 14 ClinVar variants
All ClinVar germline S100A11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
14 Uncertain significance
Full S100A11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- S100A11 p.Asn31Asp Uncertain significance Single submitter
- S100A11 p.Asp68Tyr Uncertain significance Single submitter
- S100A11 p.Asp76His Uncertain significance Single submitter
- S100A11 p.Glu79Lys Uncertain significance Single submitter
- S100A11 p.Leu87Pro Uncertain significance Single submitter
- S100A11 p.Ser71Thr Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- S100A11 p.Ala98Pro Uncertain significance Single submitter
- S100A11 p.Glu15Lys Uncertain significance Single submitter
- S100A11 p.His92Arg Uncertain significance Single submitter
- S100A11 p.Leu83Met Uncertain significance Single submitter
- S100A11 p.Phe95Ser Uncertain significance Single submitter
- S100A11 p.Pro100Ala Uncertain significance Single submitter
- S100A11 p.Thr37Ile Uncertain significance Single submitter
- S100A11 p.Thr8Ile Uncertain significance Single submitter
All S100A11 variants
Uncertain significance 14
- p.Ala98Pro Single submitter ⚠
- p.Asn31Asp Single submitter ⚠
- p.Asp68Tyr Single submitter ⚠
- p.Asp76His Single submitter ⚠
- p.Glu15Lys Single submitter ⚠
- p.Glu79Lys Single submitter ⚠
- p.His92Arg Single submitter ⚠
- p.Leu83Met Single submitter ⚠
- p.Leu87Pro Single submitter ⚠
- p.Phe95Ser Single submitter ⚠
- p.Pro100Ala Single submitter ⚠
- p.Ser71Thr Single submitter ⚠
- p.Thr37Ile Single submitter ⚠
- p.Thr8Ile Single submitter ⚠