S100A4 — 11 ClinVar variants
All ClinVar germline S100A4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
4 Benign · 7 Uncertain significance
Full S100A4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- S100A4 p.Arg40Gln Uncertain significance Single submitter
- S100A4 p.Asp95Asn Uncertain significance Single submitter
- S100A4 p.Gln97Pro Uncertain significance Single submitter
- S100A4 p.Gly47Arg Uncertain significance Single submitter
- S100A4 p.Met84Leu Uncertain significance Single submitter
- S100A4 p.Ser64Asn Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All S100A4 variants
Benign 4
Uncertain significance 7
- p.Arg40Gln Single submitter ⚠
- p.Asp95Asn Single submitter ⚠
- p.Gln97Pro Single submitter ⚠
- p.Glu69Lys Single submitter ⚠
- p.Gly47Arg Single submitter ⚠
- p.Met84Leu Single submitter ⚠
- p.Ser64Asn Single submitter ⚠