S100A9 — 16 ClinVar variants
All ClinVar germline S100A9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
2 Benign · 5 Likely benign · 9 Uncertain significance
Full S100A9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- S100A9 p.Ala84Thr Uncertain significance Single submitter
- S100A9 p.Arg10His Uncertain significance Single submitter
- S100A9 p.Gly110Arg Uncertain significance Single submitter
- S100A9 p.Gly112Ser Uncertain significance Single submitter
- S100A9 p.Ile12Val Uncertain significance Single submitter
- S100A9 p.Pro101Ser Uncertain significance Single submitter
- S100A9 p.Val24Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All S100A9 variants
Benign 2
- p.Glu99Lys Multiple submitters
- c.151-5C>T Single submitter
Likely benign 5
- p.Asn11Ser Single submitter
- p.Asn69= Single submitter
- p.Glu96= Single submitter
- p.Gly35= Single submitter
- p.Thr2Ser Single submitter
Uncertain significance 9
- p.Ala84Thr Single submitter ⚠
- p.Arg10His Single submitter ⚠
- p.Gly110Arg Single submitter ⚠
- p.Gly112Ser Single submitter ⚠
- p.Ile12Val Single submitter ⚠
- p.Phe79Leu Single submitter ⚠
- p.Pro101Ser Single submitter ⚠
- p.Ser6Trp Single submitter ⚠
- p.Val24Ala Single submitter ⚠