S100B — 10 ClinVar variants
All ClinVar germline S100B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
10 Uncertain significance
Full S100B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- S100B p.Asp13Asn Uncertain significance Single submitter
- S100B p.His91Arg Uncertain significance Single submitter
- S100B p.Leu36Phe Uncertain significance Single submitter
- S100B p.Leu4Pro Uncertain significance Single submitter
- S100B p.Phe74Tyr Uncertain significance Single submitter
- S100B p.Ser19Pro Uncertain significance Single submitter
- S100B p.Val53Leu Uncertain significance Single submitter
- S100B p.Val9Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All S100B variants
Uncertain significance 10
- p.Asp13Asn Single submitter ⚠
- p.His91Arg Single submitter ⚠
- p.Ile12Thr Single submitter ⚠
- p.Leu36Phe Single submitter ⚠
- p.Leu45Ser Single submitter ⚠
- p.Leu4Pro Single submitter ⚠
- p.Phe74Tyr Single submitter ⚠
- p.Ser19Pro Single submitter ⚠
- p.Val53Leu Single submitter ⚠
- p.Val9Ala Single submitter ⚠