S100P — 15 ClinVar variants
All ClinVar germline S100P variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
1 Benign · 14 Uncertain significance
Full S100P gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- S100P p.Asn64Ser Uncertain significance Single submitter
- S100P p.Glu90Gln Uncertain significance Single submitter
- S100P p.Leu33Arg Uncertain significance Single submitter
- S100P p.Lys59Glu Uncertain significance Single submitter
- S100P p.Ser21Asn Uncertain significance Single submitter
- S100P p.Thr29Ser Uncertain significance Single submitter
- S100P p.Val35Gly Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- S100P p.Ala7Thr Uncertain significance Single submitter
- S100P p.Leu61Pro Uncertain significance Single submitter
- S100P p.Lys30Glu Uncertain significance Single submitter
- S100P p.Met37Ile Uncertain significance Single submitter
- S100P p.Met8Thr Uncertain significance Single submitter
- S100P p.Phe89Leu Uncertain significance Single submitter
- S100P p.Thr27Ile Uncertain significance Single submitter
All S100P variants
Benign 1
- p.Thr25= Multiple submitters
Uncertain significance 14
- p.Ala7Thr Single submitter ⚠
- p.Asn64Ser Single submitter ⚠
- p.Glu90Gln Single submitter ⚠
- p.Leu33Arg Single submitter ⚠
- p.Leu61Pro Single submitter ⚠
- p.Lys30Glu Single submitter ⚠
- p.Lys59Glu Single submitter ⚠
- p.Met37Ile Single submitter ⚠
- p.Met8Thr Single submitter ⚠
- p.Phe89Leu Single submitter ⚠
- p.Ser21Asn Single submitter ⚠
- p.Thr27Ile Single submitter ⚠
- p.Thr29Ser Single submitter ⚠
- p.Val35Gly Single submitter ⚠