S1PR5 — 71 ClinVar variants
All ClinVar germline S1PR5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
3 Benign · 1 Benign/Likely benign · 5 Likely benign · 62 Uncertain significance
Full S1PR5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- S1PR5 p.Ala143Thr Uncertain significance Single submitter
- S1PR5 p.Ala170Ser Uncertain significance Single submitter
- S1PR5 p.Ala190Ser Uncertain significance Single submitter
- S1PR5 p.Ala228Val Uncertain significance Single submitter
- S1PR5 p.Ala262Thr Uncertain significance Single submitter
- S1PR5 p.Ala388Asp Uncertain significance Single submitter
- S1PR5 p.Ala56Thr Uncertain significance Single submitter
- S1PR5 p.Arg139Gly Uncertain significance Single submitter
- S1PR5 p.Arg150Leu Uncertain significance Single submitter
- S1PR5 p.Arg225Leu Uncertain significance Single submitter
- S1PR5 p.Arg229Gln Uncertain significance Single submitter
- S1PR5 p.Arg311His Uncertain significance Single submitter
- S1PR5 p.Arg350His Uncertain significance Single submitter
- S1PR5 p.Asn302Lys Uncertain significance Single submitter
- S1PR5 p.Asp274Tyr Uncertain significance Single submitter
- S1PR5 p.Asp371His Uncertain significance Single submitter
- S1PR5 p.Cys277Phe Uncertain significance Single submitter
- S1PR5 p.Gln369His Uncertain significance Single submitter
- S1PR5 p.Glu394Lys Uncertain significance Single submitter
- S1PR5 p.Gly23Ser Uncertain significance Single submitter
- S1PR5 p.Gly23Val Uncertain significance Single submitter
- S1PR5 p.Gly346Glu Uncertain significance Single submitter
- S1PR5 p.Gly358Glu Uncertain significance Single submitter
- S1PR5 p.His315Gln Uncertain significance Single submitter
- S1PR5 p.Ile129Val Uncertain significance Single submitter
- S1PR5 p.Ile215Ser Uncertain significance Single submitter
- S1PR5 p.Leu101Val Uncertain significance Single submitter
- S1PR5 p.Leu167Pro Uncertain significance Single submitter
- S1PR5 p.Leu179Pro Uncertain significance Single submitter
- S1PR5 p.Leu211Val Uncertain significance Single submitter
- S1PR5 p.Leu301Pro Uncertain significance Single submitter
- S1PR5 p.Leu73Pro Uncertain significance Single submitter
- S1PR5 p.Leu99Val Uncertain significance Single submitter
- S1PR5 p.Lys24Glu Uncertain significance Single submitter
- S1PR5 p.Met154Ile Uncertain significance Single submitter
- S1PR5 p.Met71Thr Uncertain significance Single submitter
- S1PR5 p.Met71Val Uncertain significance Single submitter
- S1PR5 p.Pro10Arg Uncertain significance Single submitter
- S1PR5 p.Pro368Leu Uncertain significance Single submitter
- S1PR5 p.Pro385Thr Uncertain significance Single submitter
- S1PR5 p.Pro98Ser Uncertain significance Single submitter
- S1PR5 p.Ser147Thr Uncertain significance Single submitter
- S1PR5 p.Ser237Trp Uncertain significance Single submitter
- S1PR5 p.Ser333Arg Uncertain significance Single submitter
- S1PR5 p.Thr235Ala Uncertain significance Single submitter
- S1PR5 p.Thr375Asn Uncertain significance Single submitter
- S1PR5 p.Thr375Ser Uncertain significance Single submitter
- S1PR5 p.Thr379Pro Uncertain significance Single submitter
- S1PR5 p.Val42Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- S1PR5 p.Ala200Pro Uncertain significance Single submitter
- S1PR5 p.Ala316Val Uncertain significance Single submitter
- S1PR5 p.Ala38Asp Uncertain significance Single submitter
- S1PR5 p.Cys47Gly Uncertain significance Single submitter
- S1PR5 p.Ile93Thr Uncertain significance Single submitter
- S1PR5 p.Leu186Ser Uncertain significance Single submitter
- S1PR5 p.Leu258Pro Uncertain significance Single submitter
- S1PR5 p.Leu320Arg Uncertain significance Single submitter
- S1PR5 p.Met137Ile Uncertain significance Single submitter
- S1PR5 p.Met296Thr Uncertain significance Single submitter
- S1PR5 p.Thr120Asn Uncertain significance Single submitter
- S1PR5 p.Val185Ala Uncertain significance Single submitter
All S1PR5 variants
Benign 3
- p.Leu308His Multiple submitters
- p.Tyr189= Multiple submitters
- p.Val275= Multiple submitters
Benign/Likely benign 1
- p.Gly141= Multiple submitters
Likely benign 5
- p.Ser393Ter Multiple submitters
- p.Ala143= Single submitter
- p.Cys328= Single submitter
- p.Pro332Leu Single submitter
- p.Thr238Ser Single submitter
Uncertain significance 62
- p.Ala143Thr Single submitter ⚠
- p.Ala170Ser Single submitter ⚠
- p.Ala190Ser Single submitter ⚠
- p.Ala200Pro Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Ala316Val Single submitter ⚠
- p.Ala388Asp Single submitter ⚠
- p.Ala38Asp Single submitter ⚠
- p.Ala56Thr Single submitter ⚠
- p.Arg139Gly Single submitter ⚠
- p.Arg150Leu Single submitter ⚠
- p.Arg225Leu Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Arg311His Single submitter ⚠
- p.Arg350His Single submitter ⚠
- p.Asn302Lys Single submitter ⚠
- p.Asp274Tyr Single submitter ⚠
- p.Asp371His Single submitter ⚠
- p.Cys277Phe Single submitter ⚠
- p.Cys47Gly Single submitter ⚠
- p.Gln369His Single submitter ⚠
- p.Glu394Lys Single submitter ⚠
- p.Gly23Ser Single submitter ⚠
- p.Gly23Val Single submitter ⚠
- p.Gly346Glu Single submitter ⚠
- p.Gly358Glu Single submitter ⚠
- p.His315Gln Single submitter ⚠
- p.Ile129Val Single submitter ⚠
- p.Ile215Ser Single submitter ⚠
- p.Ile93Thr Single submitter ⚠
- p.Leu101Val Single submitter ⚠
- p.Leu167Pro Single submitter ⚠
- p.Leu179Pro Single submitter ⚠
- p.Leu186Ser Single submitter ⚠
- p.Leu211Val Single submitter ⚠
- p.Leu258Pro Single submitter ⚠
- p.Leu301Pro Single submitter ⚠
- p.Leu320Arg Single submitter ⚠
- p.Leu73Pro Single submitter ⚠
- p.Leu99Val Single submitter ⚠
- p.Lys24Glu Single submitter ⚠
- p.Met137Ile Single submitter ⚠
- p.Met154Ile Single submitter ⚠
- p.Met296Thr Single submitter ⚠
- p.Met71Thr Single submitter ⚠
- p.Met71Val Single submitter ⚠
- p.Pro10Arg Single submitter ⚠
- p.Pro368Leu Single submitter ⚠
- p.Pro385Thr Single submitter ⚠
- p.Pro98Ser Single submitter ⚠
- p.Ser147Thr Single submitter ⚠
- p.Ser237Trp Single submitter ⚠
- p.Ser333Arg Single submitter ⚠
- p.Thr120Asn Single submitter ⚠
- p.Thr235Ala Single submitter ⚠
- p.Thr375Asn Single submitter ⚠
- p.Thr375Ser Single submitter ⚠
- p.Thr379Pro Single submitter ⚠
- p.Val123Met Single submitter
- p.Val185Ala Single submitter ⚠
- p.Val42Leu Single submitter ⚠