SARM1 — 6 ClinVar variants
All ClinVar germline SARM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
1 Benign/Likely benign · 2 Likely benign · 3 Uncertain significance
Full SARM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
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SARM1 p.Tyr501His
Uncertain significance
Single submitter
amyotrophic lateral sclerosis
All SARM1 variants
Benign/Likely benign 1
- p.Ser183= Multiple submitters TMEM199-CDG
Uncertain significance 3
- p.Ala388Ser Single submitter SARM1-related disorder ⚠
- p.Ala9Pro Single submitter ⚠
- p.Tyr501His Single submitter amyotrophic lateral sclerosis ⚠