SBK3 — 54 ClinVar variants
All ClinVar germline SBK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
54 Uncertain significance
Full SBK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- SBK3 p.Ala117Thr Uncertain significance Single submitter
- SBK3 p.Ala196Thr Uncertain significance Single submitter
- SBK3 p.Ala256Thr Uncertain significance Single submitter
- SBK3 p.Ala60Thr Uncertain significance Single submitter
- SBK3 p.Arg112Gly Uncertain significance Single submitter
- SBK3 p.Arg142Gln Uncertain significance Single submitter
- SBK3 p.Arg178His Uncertain significance Single submitter
- SBK3 p.Arg188Gln Uncertain significance Single submitter
- SBK3 p.Arg32Trp Uncertain significance Single submitter
- SBK3 p.Arg3Cys Uncertain significance Single submitter
- SBK3 p.Arg40Gln Uncertain significance Single submitter
- SBK3 p.Arg47Gln Uncertain significance Single submitter
- SBK3 p.Arg4Thr Uncertain significance Single submitter
- SBK3 p.Arg75His Uncertain significance Single submitter
- SBK3 p.Arg92Cys Uncertain significance Single submitter
- SBK3 p.Arg92His Uncertain significance Single submitter
- SBK3 p.Asp173Tyr Uncertain significance Single submitter
- SBK3 p.Asp183His Uncertain significance Single submitter
- SBK3 p.Asp224Asn Uncertain significance Single submitter
- SBK3 p.Gln146His Uncertain significance Single submitter
- SBK3 p.Gly55Ser Uncertain significance Single submitter
- SBK3 p.Leu147Trp Uncertain significance Single submitter
- SBK3 p.Leu154Phe Uncertain significance Single submitter
- SBK3 p.Leu181Pro Uncertain significance Single submitter
- SBK3 p.Leu80Met Uncertain significance Single submitter
- SBK3 p.Lys48Thr Uncertain significance Single submitter
- SBK3 p.Ser127Ile Uncertain significance Single submitter
- SBK3 p.Thr203Met Uncertain significance Single submitter
- SBK3 p.Thr34Asn Uncertain significance Single submitter
- SBK3 p.Thr83Asn Uncertain significance Single submitter
- SBK3 p.Tyr113Cys Uncertain significance Single submitter
- SBK3 p.Val175Ile Uncertain significance Single submitter
- SBK3 p.Val94Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- SBK3 p.Ala121Val Uncertain significance Single submitter
- SBK3 p.Arg188Trp Uncertain significance Single submitter
- SBK3 p.Arg220Trp Uncertain significance Single submitter
- SBK3 p.Arg24Gln Uncertain significance Single submitter
- SBK3 p.Arg24Trp Uncertain significance Single submitter
- SBK3 p.Arg40Pro Uncertain significance Single submitter
- SBK3 p.Arg40Trp Uncertain significance Single submitter
- SBK3 p.Arg75Cys Uncertain significance Single submitter
- SBK3 p.Arg76Trp Uncertain significance Single submitter
- SBK3 p.Gln118His Uncertain significance Single submitter
- SBK3 p.Gly182Glu Uncertain significance Single submitter
- SBK3 p.Leu108Arg Uncertain significance Single submitter
- SBK3 p.Phe252Val Uncertain significance Single submitter
- SBK3 p.Phe84Val Uncertain significance Single submitter
- SBK3 p.Pro195His Uncertain significance Single submitter
- SBK3 p.Pro213Leu Uncertain significance Single submitter
- SBK3 p.Pro214Ser Uncertain significance Single submitter
- SBK3 p.Val69Met Uncertain significance Single submitter
All SBK3 variants
Uncertain significance 54
- p.Ala117Thr Single submitter ⚠
- p.Ala121Val Single submitter ⚠
- p.Ala196Thr Single submitter ⚠
- p.Ala256Thr Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Arg112Gly Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg178His Single submitter ⚠
- p.Arg188Gln Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg24Gln Single submitter ⚠
- p.Arg24Trp Single submitter ⚠
- p.Arg32Trp Single submitter ⚠
- p.Arg3Cys Single submitter ⚠
- p.Arg40Gln Single submitter ⚠
- p.Arg40Pro Single submitter ⚠
- p.Arg40Trp Single submitter ⚠
- p.Arg47Gln Single submitter ⚠
- p.Arg4Thr Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Arg75His Single submitter ⚠
- p.Arg76Trp Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Asp173Tyr Single submitter ⚠
- p.Asp183His Single submitter ⚠
- p.Asp224Asn Single submitter ⚠
- p.Cys209Phe Single submitter
- p.Gln118His Single submitter ⚠
- p.Gln146His Single submitter ⚠
- p.Gly182Glu Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Leu108Arg Single submitter ⚠
- p.Leu147Trp Single submitter ⚠
- p.Leu154Phe Single submitter ⚠
- p.Leu181Pro Single submitter ⚠
- p.Leu219Arg Single submitter
- p.Leu80Met Single submitter ⚠
- p.Lys48Thr Single submitter ⚠
- p.Phe252Val Single submitter ⚠
- p.Phe84Val Single submitter ⚠
- p.Pro195His Single submitter ⚠
- p.Pro205Leu Single submitter
- p.Pro213Leu Single submitter ⚠
- p.Pro214Ser Single submitter ⚠
- p.Ser127Ile Single submitter ⚠
- p.Thr203Met Single submitter ⚠
- p.Thr34Asn Single submitter ⚠
- p.Thr83Asn Single submitter ⚠
- p.Tyr113Cys Single submitter ⚠
- p.Val175Ile Single submitter ⚠
- p.Val69Met Single submitter ⚠
- p.Val94Ile Single submitter ⚠