SCFD1 — 71 ClinVar variants
All ClinVar germline SCFD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Conflicting · 1 Benign · 69 Uncertain significance
Full SCFD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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SCFD1 p.Thr433Ala
Conflicting
Single submitter
amyotrophic lateral sclerosis
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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SCFD1 p.Ile70Thr
Uncertain significance
Multiple submitters
amyotrophic lateral sclerosis
- SCFD1 p.Ala134Val Uncertain significance Single submitter
- SCFD1 p.Ala206Asp Uncertain significance Single submitter
- SCFD1 p.Ala371Val Uncertain significance Single submitter
- SCFD1 p.Ala498Thr Uncertain significance Single submitter
- SCFD1 p.Ala503Thr Uncertain significance Single submitter
- SCFD1 p.Arg107Gln Uncertain significance Single submitter
- SCFD1 p.Asn108Ser Uncertain significance Single submitter
- SCFD1 p.Asn238Thr Uncertain significance Single submitter
- SCFD1 p.Asn264Ser Uncertain significance Single submitter
- SCFD1 p.Asp158Asn Uncertain significance Single submitter
- SCFD1 p.Asp286Val Uncertain significance Single submitter
- SCFD1 p.Asp482Gly Uncertain significance Single submitter
- SCFD1 p.Cys103Phe Uncertain significance Single submitter
- SCFD1 p.Cys212Tyr Uncertain significance Single submitter
- SCFD1 p.Gln109Arg Uncertain significance Single submitter
- SCFD1 p.Gln635Glu Uncertain significance Single submitter
- SCFD1 p.Glu344Gly Uncertain significance Single submitter
- SCFD1 p.Glu590Lys Uncertain significance Single submitter
- SCFD1 p.Gly299Glu Uncertain significance Single submitter
- SCFD1 p.Gly366Glu Uncertain significance Single submitter
- SCFD1 p.Gly370Arg Uncertain significance Single submitter
- SCFD1 p.Gly370Glu Uncertain significance Single submitter
- SCFD1 p.Gly69Arg Uncertain significance Single submitter
- SCFD1 p.Ile119Val Uncertain significance Single submitter
- SCFD1 p.Ile122Val Uncertain significance Single submitter
- SCFD1 p.Ile209Val Uncertain significance Single submitter
- SCFD1 p.Ile442Val Uncertain significance Single submitter
- SCFD1 p.Ile459Thr Uncertain significance Single submitter
- SCFD1 p.Ile619Leu Uncertain significance Single submitter
- SCFD1 p.Leu519Ile Uncertain significance Single submitter
- SCFD1 p.Met517Val Uncertain significance Single submitter
- SCFD1 p.Met573Val Uncertain significance Single submitter
- SCFD1 p.Phe198Ser Uncertain significance Single submitter
- SCFD1 p.Phe422Val Uncertain significance Single submitter
- SCFD1 p.Phe530Ser Uncertain significance Single submitter
- SCFD1 p.Pro333Ala Uncertain significance Single submitter
- SCFD1 p.Pro587Ser Uncertain significance Single submitter
- SCFD1 p.Pro87Ser Uncertain significance Single submitter
- SCFD1 p.Ser504Leu Uncertain significance Single submitter
- SCFD1 p.Ser57Phe Uncertain significance Single submitter
- SCFD1 p.Thr184Met Uncertain significance Single submitter
- SCFD1 p.Thr245Ala Uncertain significance Single submitter
- SCFD1 p.Thr245Ile Uncertain significance Single submitter
- SCFD1 p.Thr276Ile Uncertain significance Single submitter
- SCFD1 p.Thr449Ser Uncertain significance Single submitter
- SCFD1 p.Thr481Ile Uncertain significance Single submitter
- SCFD1 p.Thr548Asn Uncertain significance Single submitter
- SCFD1 p.Tyr568His Uncertain significance Single submitter
- SCFD1 p.Tyr610Cys Uncertain significance Single submitter
- SCFD1 p.Val162Ile Uncertain significance Single submitter
- SCFD1 p.Val171Ile Uncertain significance Single submitter
- SCFD1 p.Val89Ile Uncertain significance Single submitter
- SCFD1 p.Val92Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- SCFD1 p.Arg357Gln Uncertain significance Single submitter
- SCFD1 p.Asn30Ser Uncertain significance Single submitter
- SCFD1 p.Asn486His Uncertain significance Single submitter
- SCFD1 p.Asp444Glu Uncertain significance Single submitter
- SCFD1 p.Gln589Glu Uncertain significance Single submitter
- SCFD1 p.Gly306Asp Uncertain significance Single submitter
- SCFD1 p.Gly363Arg Uncertain significance Single submitter
- SCFD1 p.Gly616Asp Uncertain significance Single submitter
- SCFD1 p.Met220Val Uncertain significance Single submitter
- SCFD1 p.Met532Val Uncertain significance Single submitter
- SCFD1 p.Met68Arg Uncertain significance Single submitter
- SCFD1 p.Met68Thr Uncertain significance Single submitter
- SCFD1 p.Phe200Leu Uncertain significance Single submitter
- SCFD1 p.Val261Ala Uncertain significance Single submitter
All SCFD1 variants
Conflicting classifications of pathogenicity 1
- p.Thr433Ala Single submitter amyotrophic lateral sclerosis ⚠
Benign 1
- c.755+7C>T Single submitter
Uncertain significance 69
- p.Ile70Thr Multiple submitters amyotrophic lateral sclerosis ⚠
- p.Ala134Val Single submitter ⚠
- p.Ala206Asp Single submitter ⚠
- p.Ala371Val Single submitter ⚠
- p.Ala498Thr Single submitter ⚠
- p.Ala503Thr Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg357Gln Single submitter ⚠
- p.Asn108Ser Single submitter ⚠
- p.Asn238Thr Single submitter ⚠
- p.Asn264Ser Single submitter ⚠
- p.Asn30Ser Single submitter ⚠
- p.Asn486His Single submitter ⚠
- p.Asp158Asn Single submitter ⚠
- p.Asp286Val Single submitter ⚠
- p.Asp444Glu Single submitter ⚠
- p.Asp482Gly Single submitter ⚠
- p.Cys103Phe Single submitter ⚠
- p.Cys212Tyr Single submitter ⚠
- p.Gln109Arg Single submitter ⚠
- p.Gln589Glu Single submitter ⚠
- p.Gln635Glu Single submitter ⚠
- p.Glu344Gly Single submitter ⚠
- p.Glu590Lys Single submitter ⚠
- p.Gly299Glu Single submitter ⚠
- p.Gly306Asp Single submitter ⚠
- p.Gly363Arg Single submitter ⚠
- p.Gly366Glu Single submitter ⚠
- p.Gly370Arg Single submitter ⚠
- p.Gly370Glu Single submitter ⚠
- p.Gly616Asp Single submitter ⚠
- p.Gly69Arg Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Ile122Val Single submitter ⚠
- p.Ile209Val Single submitter ⚠
- p.Ile442Val Single submitter ⚠
- p.Ile459Thr Single submitter ⚠
- p.Ile619Leu Single submitter ⚠
- p.Leu519Ile Single submitter ⚠
- p.Met220Val Single submitter ⚠
- p.Met517Val Single submitter ⚠
- p.Met532Val Single submitter ⚠
- p.Met573Val Single submitter ⚠
- p.Met68Arg Single submitter ⚠
- p.Met68Thr Single submitter ⚠
- p.Phe198Ser Single submitter ⚠
- p.Phe200Leu Single submitter ⚠
- p.Phe422Val Single submitter ⚠
- p.Phe530Ser Single submitter ⚠
- p.Pro333Ala Single submitter ⚠
- p.Pro587Ser Single submitter ⚠
- p.Pro87Ser Single submitter ⚠
- p.Ser504Leu Single submitter ⚠
- p.Ser57Phe Single submitter ⚠
- p.Thr184Met Single submitter ⚠
- p.Thr245Ala Single submitter ⚠
- p.Thr245Ile Single submitter ⚠
- p.Thr276Ile Single submitter ⚠
- p.Thr449Ser Single submitter ⚠
- p.Thr481Ile Single submitter ⚠
- p.Thr548Asn Single submitter ⚠
- p.Tyr568His Single submitter ⚠
- p.Tyr610Cys Single submitter ⚠
- p.Val162Ile Single submitter ⚠
- p.Val171Ile Single submitter ⚠
- p.Val261Ala Single submitter ⚠
- p.Val595Leu Single submitter
- p.Val89Ile Single submitter ⚠
- p.Val92Leu Single submitter ⚠