Sugi Variant

Sugi Variant/SCN10A

SCN10A — 2290 ClinVar variants

All ClinVar germline SCN10A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1230 flagged for review →

2 Likely pathogenic · 175 Conflicting · 53 Benign · 51 Benign/Likely benign · 723 Likely benign · 1286 Uncertain significance

Full SCN10A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 1230

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 103

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 817

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 817

Predictors split 310

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 310

All SCN10A variants

Likely pathogenic 2

Conflicting classifications of pathogenicity 175

Benign 53

Benign/Likely benign 51

Likely benign 723

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 1286

Showing the top 300 by review status; the full set is in the sitemap.